肉豆蔻酸单甘油酯

肉豆蔻酸单甘油酯用途

1-Monomyristin 提取自 Serenoa repens,抑制 2-油酰甘油的水解 (IC50=32 μM) 和脂肪酸酰胺水解酶 (FAAH) 活性 (IC50=18 μM)。1-Monomyristin 对金黄色葡萄球菌和聚集性放线菌有抗菌活性,对白色念珠菌也有抗真菌活性。

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肉豆蔻酸单甘油酯名称

[ CAS 号 ]:
589-68-4

[ 中文名 ]:
甘油单肉豆寇酸酯

[ 英文名 ]:
Monomyristin

[中文别名 ]:

[英文别名 ]:

Myristic acid 1-monoglyceride
Tetradecanoic acid, 2,3-dihydroxypropyl ester
MFCD00046760
2,3-Dihydroxypropyl myristate
1-monomyristoylglycerol
UNII:SMJ2192F1R
rac-Glycerol 1-myristate

肉豆蔻酸单甘油酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

信号通路 >> 代谢酶/蛋白酶 >> FAAH

信号通路 >> 神经信号通路 >> FAAH

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

IC50: 18 μM (FAAH)[2]

[参考文献]

[1]. Shimada H, et al. Biologically active acylglycerides from the berries of saw-palmetto (Serenoa repens). J Nat Prod. 1997 Apr;60(4):417-8.

[2]. Vandevoorde S, et al. Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase. Biochem Biophys Res Commun. 2005 Nov 11;337(1):104-9.

[3]. Jumina, et al. Monomyristin and Monopalmitin Derivatives: Synthesis and Evaluation as Potential Antibacterial and Antifungal Agents. Molecules. 2018 Nov 29;23(12). pii: E3141

肉豆蔻酸单甘油酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
424.8±25.0 °C at 760 mmHg

[ 熔点 ]:
68-70ºC

[ 分子式 ]:
C₁₇H₃₄O₄

[ 分子量 ]:
302.449

[ 闪点 ]:
141.3±16.7 °C

[ 精确质量 ]:
302.245697

[ PSA ]:
66.76000

[ LogP ]:
5.10

[ 外观性状 ]:
白色 -极淡的黄色晶体 -粉末

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.468

[ 储存条件 ]:
室温，干燥

肉豆蔻酸单甘油酯MSDS

肉豆蔻酸单甘油酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2915900090

肉豆蔻酸单甘油酯合成路线

肉豆蔻酸单甘油酯上下游产品

肉豆蔻酸单甘油酯上游产品

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肉豆蔻酸单甘油酯海关

[ 海关编码 ]: 2915900090

[ 中文概述 ]:
2915900090. 其他饱和无环一元羧酸及其酸酐（酰卤、过氧）化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

肉豆蔻酸单甘油酯文献

Adsorption of 1-Monoglycerides at the Hexane/Water Interface.

J. Colloid. Interface Sci. 220 , 374-379, (1999)

The interfacial tension of a hexane solution of 1-monolaurin against water was measured as a function of temperature and concentration under atmospheric pressure. The thermodynamic quantity changes as...

Structure of nonionic surfactant (glycerol alpha-monomyristate) micelles in organic solvents: a SAXS study.

J. Phys. Chem. B 113 , 6290-6298, (2009)

In this paper we present the study of reverse micellar aggregates formed by glycerol alpha-monomyristate (C(14)G(1)) in different organic solvents. We have investigated the structure (mainly shape and...

Absorption properties of micellar lipid metabolites into Caco2 cells.

Lipids 42 , 613-619, (2007)

To elucidate the absorption characteristics of dietary lipids in the human intestine, we investigated the cellular uptake of lipid metabolites using a differential monolayer of the Caco2 cells. As lip...

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