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DL-蛋氨酸

DL-蛋氨酸用途

DL-Methionine 是一种含有硫的必需氨基酸,具有氧化应激防御作用。DL-Methionine 可用于动物的天然饲料,还可以杀死马铃薯上的马铃薯金线虫 (H. rostochiensis)。

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DL-蛋氨酸名称

[ CAS 号 ]:
59-51-8

[ 中文名 ]:
DL-甲硫氨酸

[ 英文名 ]:
DL-Methionine

[中文别名 ]:

[英文别名 ]:

Meonine
MFCD00063097
Metion
DL-2-Amino-4-(methylthio)butanoic acid
Neston
Urimeth
Metione
Dyprin
MET
Amurex

DL-蛋氨酸生物活性

[ 描述 ]:

DL-Methionine 是一种含有硫的必需氨基酸,具有氧化应激防御作用。DL-Methionine 可用于动物的天然饲料,还可以杀死马铃薯上的马铃薯金线虫 (H. rostochiensis)。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

[ 靶点 ]

H. rostochiensis[1]

[体外研究]

补充DL-蛋氨酸对动物生产性能的影响与日粮中粗蛋白(CP)含量密切相关。在20%粗蛋白日粮中添加DLM可降低肉仔鸡的腹部脂肪重量,而当日粮中含有23%粗蛋白时,情况并非如此。随着添加DL-蛋氨酸,胸肉产量增加,腹部脂肪含量降低,并且这种反应在以蛋白质水平较低(20.5%CP),而蛋白质水平较高(26%)[2]。

[体内研究]

DL-蛋氨酸显著降低马铃薯植株上喙突线虫的雌雄、囊和卵的数量。DL-蛋氨酸在接种后3天施用,几乎杀死所有线虫,且DL-蛋氨酸不会对植物生长产生不利影响[1]。

[参考文献]

[1]. K. evans, et al. Effects of amino acids on the reproduction of Heterodera rostochiensis. Nematologica, 1971, 17(4), 495-500.

[2]. Swennen Q, et al. Effects of dietary protein content and 2-hydroxy-4-methylthiobutanoic acid or DL-methionine supplementation on performance and oxidative status of broiler chickens. Br J Nutr. 2011 Dec;106(12):1845-54.

[3]. Garlich JD. Response of broilers to DL-methionine hydroxy analog free acid, DL-methionine, and L-methionine. Poult Sci. 1985 Aug;64(8):1541-8.

DL-蛋氨酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
306.9±37.0 °C at 760 mmHg

[ 熔点 ]:
270-273ºC

[ 分子式 ]:
C₅H₁₁NO₂S

[ 分子量 ]:
149.211

[ 闪点 ]:
139.4±26.5 °C

[ 精确质量 ]:
149.051056

[ PSA ]:
88.62000

[ LogP ]:
0.37

[ 外观性状 ]:
白色结晶粉末带有一种微弱气味

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.531

[ 储存条件 ]:
0-6°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidising agents.

[ 水溶解性 ]:
1 M HCl: 0.5 M at 20 °C, clear, colorless | 2.9 g/100 mL (20 ºC)

DL-蛋氨酸MSDS

DL-蛋氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PD0456000

CHEMICAL NAME :: Methionine, DL-

CAS REGISTRY NUMBER :: 59-51-8

LAST UPDATED :: 199706

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C5-H11-N-O2-S

MOLECULAR WEIGHT :: 149.23

WISWESSER LINE NOTATION :: QV1YZ1S1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36 gm/kg/30D-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in leukocyte (WBC) count

REFERENCE :: JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 79,101,1963

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 gm/kg/13D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight

REFERENCE :: JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 106,1714,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 39 gm/kg/20D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight

REFERENCE :: JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 106,1714,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - turkey

DOSE/DURATION :: 33600 mg/kg/4W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: POSCAL Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark St., Champaign, IL 61820) V.1- 1921- Volume(issue)/page/year: 57,699,1978 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 40 gm/kg

SEX/DURATION :: female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 33,109,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3271 No. of Facilities: 1272 (estimated) No. of Industries: 5 No. of Occupations: 27 No. of Employees: 16781 (estimated) No. of Female Employees: 4397 (estimated)

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DL-蛋氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R33

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
PD0457000

[ 海关编码 ]:
2930400000

DL-蛋氨酸合成路线

DL-蛋氨酸上下游产品

DL-蛋氨酸上游产品

DL-蛋氨酸下游产品

DL-蛋氨酸制备

1.可采用提取法制备蛋氨酸，但工业上有以下方法：1. 罗纳－普朗克工艺2. 德固萨DL-蛋氨酸工艺原料消耗定额：丙烯醛480kg/t、甲硫醇400kg/t、氰化钠420kg/t。

2.以丙烯醛为原料合成制得。

3.以丙烯醛和甲硫醇为原料，反应生成甲硫基丙醛。

产物甲硫基丙醛再与氰化钠反应生成海因。

海因在氢氧化钠存在下水解生成蛋氨酸钠。

蛋氨酸钠用硫酸中和生成DL-蛋氨酸。

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DL-蛋氨酸海关

[ 海关编码 ]: 2930400000

DL-蛋氨酸文献

The Arabidopsis cellulose synthase complex: a proposed hexamer of CESA trimers in an equimolar stoichiometry.

Plant Cell 26(12) , 4834-42, (2015)

Cellulose is the most abundant renewable polymer on Earth and a major component of the plant cell wall. In vascular plants, cellulose synthesis is catalyzed by a large, plasma membrane-localized cellu...

A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.

J. Virol. 89(9) , 4918-31, (2015)

The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early ...

Biomolecular imaging with a C60-SIMS/MALDI dual ion source hybrid mass spectrometer: instrumentation, matrix enhancement, and single cell analysis.

J. Am. Soc. Mass Spectrom. 25(11) , 1897-907, (2014)

We describe a hybrid MALDI/C(60)-SIMS Q-TOF mass spectrometer and corresponding sample preparation protocols to image intact biomolecules and their fragments in mammalian spinal cord, individual inver...

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DL-蛋氨酸

DL-蛋氨酸用途

DL-蛋氨酸名称

DL-蛋氨酸生物活性

DL-蛋氨酸物理化学性质

DL-蛋氨酸MSDS

详细MSDS(安全技术说明书)

DL-蛋氨酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

DL-蛋氨酸安全信息

DL-蛋氨酸合成路线

详细合成路线

DL-蛋氨酸上下游产品

DL-蛋氨酸上游产品

DL-蛋氨酸下游产品

DL-蛋氨酸制备

DL-蛋氨酸海关

DL-蛋氨酸文献

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