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D-蛋氨酸

D-蛋氨酸用途

Methionine (MRX-1024) 是一种有效的化学保护剂,它还可以通过激活 GABAA 受体来抑制神经元活性。

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D-蛋氨酸名称

[ CAS 号 ]:
348-67-4

[ 中文名 ]:
D-蛋氨酸

[ 英文名 ]:
D-methionine

[中文别名 ]:

[英文别名 ]:

R-Methionine
(R)-2-amino-4-(methylthio)butanoic acid
D-Methionin
d-Met
(2R)-2-amino-4-(methylsulfanyl)butanoic acid
(R)-methionine
D-Methionine
EINECS 206-483-6
(2R)-2-amino-4-methylsulfanylbutanoic acid
H-D-Met-OH

D-蛋氨酸生物活性

[ 描述 ]:

Methionine (MRX-1024) 是一种有效的化学保护剂,它还可以通过激活 GABAA 受体来抑制神经元活性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

信号通路 >> 神经信号通路 >> GABA受体

研究领域 >> 癌症

研究领域 >> 神经疾病

[ 靶点 ]

GABAA receptor[1]

[体外研究]

人血浆与甲硫氨酸(D-甲硫氨酸)和CP的温育导致Pt-D-甲硫氨酸复合物的形成,与添加顺序无关。在血浆中,早期的CP水解产物与甲硫氨酸反应形成1：1复合物,然后在稍后的时间点形成2：1化合物。这些Pt-D-蛋氨酸物种的形成在蛋氨酸保护哺乳动物生物免受CP诱导的毒性的过程中起重要作用[2]。

[体内研究]

当蛋氨酸(D-蛋氨酸)与顺铂一起给药时,细胞密度为0.8±0.070(SEM),显着大于仅用顺铂治疗的大鼠(P <0.01),而与对照或仅用D治疗的动物没有显着差异。-蛋氨酸(P> 0.05)。当单独给予蛋氨酸时,平均细胞密度为0.95±0.099(SEM),与对照组无显着差异(P> 0.05)[3]。

[细胞实验]

向血浆（2.0mL）中加入81mL的CP储备溶液，在37℃下孵育30分钟，然后加入20mL的甲硫氨酸（D-甲硫氨酸）储备溶液（40.7mg / mL）。在37℃温育10分钟和50分钟后分析所得混合物[2]。

[动物实验]

三个假对照接受0.9％盐水而不是顺铂。三只大鼠仅接受顺铂。另外三只大鼠在用顺铂治疗前30分钟接受甲硫氨酸（D-甲硫氨酸）。顺铂治疗前注射甲硫氨酸可确保在顺铂应用前服用甲硫氨酸。最后，仅用甲硫氨酸处理三只大鼠。处理后第7天处死所有12只大鼠。对于预筛选，另外两只大鼠单独用顺铂处理，并在2或21天后处死。所有大鼠用0.9％盐水[3]水合。

[参考文献]

[1]. Wu C, et al. Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition. J Neural Transm (Vienna). 2014 Jul;121(7):683-93.

[2]. Sooriyaarachchi M, et al. Chemoprotection by D-methionine against cisplatin-induced side-effects: insight from in vitrostudies using human plasma. Metallomics. 2014 Mar;6(3):532-41.

[3]. Hinduja S, et al. D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat. Neurotox Res. 2015 Apr;27(3):199-204.

[相关活性小分子]

D-蛋氨酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
306.9±37.0 °C at 760 mmHg

[ 熔点 ]:
273-275ºC

[ 分子式 ]:
C₅H₁₁NO₂S

[ 分子量 ]:
149.211

[ 闪点 ]:
139.4±26.5 °C

[ 精确质量 ]:
149.051056

[ PSA ]:
88.62000

[ LogP ]:
0.37

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.531

[ 储存条件 ]:
2~8°C

D-蛋氨酸MSDS

D-蛋氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PD0455000

CHEMICAL NAME :: Methionine, D-

CAS REGISTRY NUMBER :: 348-67-4

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H11-N-O2-S

MOLECULAR WEIGHT :: 149.23

WISWESSER LINE NOTATION :: QVYZ2S1 -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5223 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956 *** REVIEWS *** TOXICOLOGY REVIEW JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 22,2,1974

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D-蛋氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R33

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
PD0455000

[ 海关编码 ]:
2930400000

D-蛋氨酸合成路线

D-蛋氨酸上下游产品

D-蛋氨酸上游产品

D-蛋氨酸下游产品

D-蛋氨酸海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

D-蛋氨酸文献

Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.

PLoS ONE 4(5) , e5492, (2009)

The transcription factor Nrf2 is the master regulator of a cellular defense mechanism against environmental insults. The Nrf2-mediated antioxidant response is accomplished by the transcription of a ba...

Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition.

J. Neural Transm. Gen. Sect. 121(7) , 683-93, (2014)

Antioxidants are well known for their neuroprotective properties against reactive oxygen species in cortical neurons and auditory cells. We recently identified L-carnitine and D-methionine to be among...

D-methionine (D-met) significantly rescues noise-induced hearing loss: timing studies.

Hear. Res. 282 , 138-144, (2011)

We have previously reported rescue from noise-induced auditory brainstem response (ABR) threshold shifts with d-methionine (d-met) administration 1 h after noise exposure. The present study investigat...

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