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根皮素

根皮素用途

Phloretin(NSC 407292; RJC 02792)是天然多酚,能抑制通过SGLT1、SGLT2和GLUT1的葡萄糖转运。

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根皮素作用

用作药品，化妆品助剂，食品添加剂等

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根皮素名称

[ CAS 号 ]:
60-82-2

[ 中文名 ]:
根皮素

[ 英文名 ]:
Phloretin

[中文别名 ]:

[英文别名 ]:

QR CQ EQ BV2R DQ
Dihydronaringenin
2',4',6',4-tetrahydroxydihydrochalcone
β-(p-Hydroxyphenyl)phloropropiophenone
phloretol
4,2',4',6'-tetrahydroxydihydrochalcone
b-(p-Hydroxyphenyl)phloropropiophenone
UNII-S5J5OE47MK
EINECS 200-488-7
Phloretin

根皮素生物活性

[ 描述 ]:

Phloretin(NSC 407292; RJC 02792)是天然多酚,能抑制通过SGLT1、SGLT2和GLUT1的葡萄糖转运。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> SGLT

研究领域 >> 代谢疾病

天然产物 >> 醌类

[参考文献]

[1]. CHAN SS, LOTSPEICH WD. Comparative effects of phlorizin and phloretin on glucose transport in the cat kidney. Am J Physiol. 1962 Dec;203:975-9.

[2]. Huang WC, Chang WT, Wu SJ, Phloretin and phlorizin promote lipolysis and inhibit inflammation in mouse 3T3-L1 cells and in macrophage-adipocyte co-cultures. Mol Nutr Food Res. 2013 Jun 17.

[3]. Luo H, Wang YJ, Chen J, Phloretin induces apoptosis of BEL-7402 cells in vitro. Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jul;28(7):1249-51.

[4]. Kasahara T, Kasahara M. Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces cerevisiae. Biochem J. 1996 Apr 1;315 ( Pt 1):177-82.

[5]. Najafian M, Jahromi MZ, Nowroznejhad MJ, Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats. Mol Biol Rep. 2012 May;39(5):5299-306.

[相关活性小分子]

根皮素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
534.4±29.0 °C at 760 mmHg

[ 熔点 ]:
~260 °C

[ 分子式 ]:
C₁₅H₁₄O₅

[ 分子量 ]:
274.269

[ 闪点 ]:
291.1±20.8 °C

[ 精确质量 ]:
274.084137

[ PSA ]:
97.99000

[ LogP ]:
3.50

[ 外观性状 ]:
结晶固体

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.685

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
soluble

根皮素MSDS

根皮素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S37/39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2942000000

根皮素合成路线

根皮素上下游产品

根皮素上游产品

根皮素下游产品

根皮素海关

[ 海关编码 ]: 2914501900

[ 中文概述 ]:
2914501900 其他酮酚。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

根皮素文献

Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression.

Oncotarget 6 , 37281-99, (2015)

Melanoma is a largely incurable skin malignancy owing to the underlying molecular and metabolic heterogeneity confounded by the development of resistance. Cancer cells have metabolic flexibility in ch...

Antagonistic control of a dual-input mammalian gene switch by food additives.

Nucleic Acids Res. 42(14) , e116, (2014)

Synthetic biology has significantly advanced the design of mammalian trigger-inducible transgene-control devices that are able to programme complex cellular behaviour. Fruit-based benzoate derivatives...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

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根皮素

根皮素用途

根皮素作用

根皮素名称

根皮素生物活性

根皮素物理化学性质

根皮素MSDS

详细MSDS(安全技术说明书)

根皮素安全信息

根皮素合成路线

详细合成路线

根皮素上下游产品

根皮素上游产品

根皮素下游产品

根皮素海关

根皮素文献

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