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色胺

色胺用途

Tryptamine是一种单胺生物碱,类似于其它微量胺,被认为是神经调节剂或神经递质。

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色胺名称

[ CAS 号 ]:
61-54-1

[ 中文名 ]:
色胺

[ 英文名 ]:
tryptamine

[中文别名 ]:

[英文别名 ]:

2-(1H-Indol-3-yl)ethylamine
Tryptamine
1H-Indole-3-ethanamine
2-indol-3-yl-ethylamine
Indole-ethylamine
L-TRYPTAMINE
EINECS 200-510-5
2-Indol-3-yl-aethylamin
Tryptamin
3-Indoleethanamine

色胺生物活性

[ 描述 ]:

Tryptamine是一种单胺生物碱,类似于其它微量胺,被认为是神经调节剂或神经递质。

[ 相关类别 ]:

天然产物 >> 生物碱

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Jones RS, et al. Tryptamine: a neuromodulator or neurotransmitter in mammalian brain? Prog Neurobiol. 1982;19(1-2):117-39.

[相关活性小分子]

色胺物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
378.8±0.0 °C at 760 mmHg

[ 熔点 ]:
113-116 °C(lit.)

[ 分子式 ]:
C₁₀H₁₂N₂

[ 分子量 ]:
160.216

[ 闪点 ]:
187.7±8.1 °C

[ 精确质量 ]:
160.100052

[ PSA ]:
41.81000

[ LogP ]:
1.38

[ 外观性状 ]:
结晶

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.669

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
negligible

色胺MSDS

色胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL4020000

CHEMICAL NAME :: Indole, 3-(2-aminoethyl)-

CAS REGISTRY NUMBER :: 61-54-1

BEILSTEIN REFERENCE NO. :: 0125513

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H12-N2

MOLECULAR WEIGHT :: 160.24

WISWESSER LINE NOTATION :: T56 BMJ D2Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 223 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 66,1692,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,453,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA. Volume(issue)/page/year: 22,313,1970

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色胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
20/21/22-36/37/38-41-37/38-22

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NL4020000

[ 海关编码 ]:
29339990

色胺合成路线

色胺上下游产品

色胺上游产品

色胺下游产品

色胺海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

色胺文献

Use of Commercial Dry Yeast Products Rich in Mannoproteins for White and Rosé Sparkling Wine Elaboration.

J. Agric. Food Chem. 63 , 5670-81, (2015)

In sparkling wines, mannoproteins released during yeast autolysis largely affect their final quality. This process is very slow and may take several months. The aim of this work was to study the effec...

Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline.

Chem. Commun. (Camb.) 49(19) , 1954-6, (2013)

Starting from (S)-tryptophanol, a formal synthesis of ent-rhynchophylline and ent-isorhynchophylline, involving stereoselective cyclocondensation, spirocyclization, and alkylation reactions, and the f...

A separation of tyramine on a 2-(4-methoxyphenyl)ethylamine imprinted polymer: an answer from theoretical and experimental studies.

Talanta 129 , 155-64, (2014)

A 2-(4-methoxyphenyl)ethylamine imprinted polymer (MIP) was successfully applied for the selective separation of tyramine. A computational analysis was used to predict the affinity of the polymer matr...

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色胺