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柠康酸酐

柠康酸酐用途

【用途一】
用于合成马来酰亚胺、二环吡咯烷和三元共聚物的常用试剂，也用于保护N-末端氨基酸。

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柠康酸酐名称

[ CAS 号 ]:
616-02-4

[ 中文名 ]:
柠康酸酐

[ 英文名 ]:
Citraconic anhydride

[中文别名 ]:

[英文别名 ]:

EINECS 210-459-0
3-methylfuran-2,5-dione
MFCD00005522

柠康酸酐物理化学性质

[ 密度 ]:
1.247 g/mL at 25 °C(lit.)

[ 沸点 ]:
213-214 °C(lit.)

[ 熔点 ]:
6-10 °C(lit.)

[ 分子式 ]:
C₅H₄O₃

[ 分子量 ]:
112.08300

[ 闪点 ]:
215 °F

[ 精确质量 ]:
112.01600

[ PSA ]:
43.37000

[ LogP ]:
0.01610

[ 外观性状 ]:
透明无色至淡黄色液体

[ 蒸汽密度 ]:
4 (vs air)

[ 折射率 ]:
n20/D 1.471(lit.)

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
decomposes

柠康酸酐MSDS

柠康酸酐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GE6825000

CHEMICAL NAME :: Citraconic anhydride

CAS REGISTRY NUMBER :: 616-02-4

BEILSTEIN REFERENCE NO. :: 0001835

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C5-H4-O3

MOLECULAR WEIGHT :: 112.09

WISWESSER LINE NOTATION :: T5VOVJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 218 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SHELL* Shell Chemical Company. (P.O. Box 4320, Houston, TX 77210)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944

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柠康酸酐安全信息

[ 符号 ]:

GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H311-H314-H317-H334-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R24;R34;R42/43

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S28A

[ 危险品运输编码 ]:
UN 2810 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
GE6825000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29171990

柠康酸酐合成路线

柠康酸酐上下游产品

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柠康酸酐下游产品

柠康酸酐海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

柠康酸酐文献

MALDI imaging mass spectrometry profiling of N-glycans in formalin-fixed paraffin embedded clinical tissue blocks and tissue microarrays.

PLoS ONE 9(9) , e106255, (2014)

A recently developed matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) method to spatially profile the location and distribution of multiple N-linked glycan species in ...

Polymeric micelles with citraconic amide as pH-sensitive bond in backbone for anticancer drug delivery.

Int. J. Pharm. 471(1-2) , 28-36, (2014)

A novel pH-sensitive polymeric micelle was reported. Methoxy poly(ethylene glycol)-b-poly(ϵ-caprolactone) copolymer with citraconic amide as pH-sensitive bond was synthesized (mPEG-pH-PCL). The copoly...

Pre-cultivation of adipose tissue-derived microvascular fragments in porous scaffolds does not improve their in vivo vascularisation potential.

Eur. Cell. Mater. 29 , 190-200; discussion 200-1, (2015)

Adipose tissue-derived microvascular fragments represent promising vascularisation units for implanted tissue constructs. However, their reassembly into functional microvascular networks takes several...

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