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柠康酸

柠康酸用途

Citraconic acid属于甲基支链脂肪酸的有机化合物类。

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柠康酸名称

[ CAS 号 ]:
498-23-7

[ 中文名 ]:
柠康酸

[ 英文名 ]:
Citraconic acid

[中文别名 ]:

[英文别名 ]:

EINECS 207-858-7
Maleic acid,methyl
cis-2-methylbutenedioic acid
2-Methylmaleic acid
Citraconicacid
Kyselina citrakonova
methyl-maleicaci
METHYLMALEIC ACID
Citraconic acid
2-methyl-2-butenedioic acid

柠康酸生物活性

[ 描述 ]:

Citraconic acid属于甲基支链脂肪酸的有机化合物类。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Pulat M, et al. Lipase release through semi-interpenetrating polymer network hydrogels based on chitosan, acrylamide, and citraconic acid. Artif Cells Nanomed Biotechnol. 2014 Apr;42(2):121-7.

[相关活性小分子]

柠康酸物理化学性质

[ 密度 ]:
1,62 g/cm3

[ 沸点 ]:
336ºC

[ 熔点 ]:
88-94 °C(lit.)

[ 分子式 ]:
C₅H₆O₄

[ 分子量 ]:
130.09900

[ 精确质量 ]:
130.02700

[ PSA ]:
74.60000

[ LogP ]:
0.10190

[ 外观性状 ]:
吸湿的,灰白色粉末

[ 蒸汽压 ]:
2.09E-05mmHg at 25°C

[ 储存条件 ]:
室温，密封，干燥

[ 水溶解性 ]:
FREELY SOLUBLE

柠康酸MSDS

柠康酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GE6650000

CHEMICAL NAME :: Citraconic acid

CAS REGISTRY NUMBER :: 498-23-7

BEILSTEIN REFERENCE NO. :: 1722679

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H6-O4

MOLECULAR WEIGHT :: 130.11

WISWESSER LINE NOTATION :: QVY1&U1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1320 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2260 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - other changes

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Gastrointestinal - gastritis

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964

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柠康酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S36-S37/39-S26

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
GE6650000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2917190090

柠康酸合成路线

柠康酸上下游产品

柠康酸上游产品

柠康酸下游产品

柠康酸制备

本品在180℃加热，与硝酸或氢氧化钾作用得中康酸；与钠汞剂作用得甲基丁二酸。由蒸馏柠檬酸而得。

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柠康酸海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

柠康酸文献

Highly sensitive GC/MS/MS method for quantitation of amino and nonamino organic acids.

Anal. Chem. 83(7) , 2705-11, (2011)

Metabolite profiling methods are important tools for measurement of metabolite pools in biological systems. While most metabolite profiling methods report relative intensities or depend on a few inter...

The antipsoriatic agent monomethylfumarate has antiproliferative, prodifferentiative, and anti-inflammatory effects on keratinocytes.

J. Pharmacol. Exp. Ther. 352(1) , 90-7, (2015)

Monomethylfumarate (MMF) is thought to be the bioactive ingredient of the drug Fumaderm (Biogen Idec, Cambridge, MA), licensed in Germany since 1994 for the treatment of moderate-to-severe psoriasis. ...

Effects of fumaric acid esters on blood-brain barrier tight junction proteins.

Neurosci. Lett. 555 , 165-70, (2013)

The blood-brain barrier (BBB) is composed of a network of tight junctions (TJ) which interconnect cerebral endothelial cells (EC). Alterations in the TJ proteins are common in inflammatory diseases of...

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柠康酸

柠康酸用途

柠康酸名称

柠康酸生物活性

柠康酸物理化学性质

柠康酸MSDS

详细MSDS(安全技术说明书)

柠康酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

柠康酸安全信息

柠康酸合成路线

详细合成路线

柠康酸上下游产品

柠康酸上游产品

柠康酸下游产品

柠康酸制备

柠康酸海关

柠康酸文献

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