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黄嘌呤

黄嘌呤用途

Xanthine 是一种广泛分布于人体及其他生物体器官及体液中的一种嘌呤碱,常用作温和的兴奋剂和支气管扩张剂,特别用于治疗哮喘症状。

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黄嘌呤名称

[ CAS 号 ]:
69-89-6

[ 中文名 ]:
2,6-二羟基嘌呤

[ 英文名 ]:
2,6-Dihydroxypurine

[中文别名 ]:

[英文别名 ]:

UREOUS ACID
Xan
xanthicoxide
Dioxopurine
9H-xanthine
2,5-DIFLUOROTHIOBENZAMIDE
usafcb-17
Xanthine
9H-Purine-2,6(1H,3H)-dione
Purine-2,6(1H,3H)-dione

黄嘌呤生物活性

[ 描述 ]:

Xanthine 是一种广泛分布于人体及其他生物体器官及体液中的一种嘌呤碱,常用作温和的兴奋剂和支气管扩张剂,特别用于治疗哮喘症状。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

许多兴奋剂来自黄嘌呤,包括咖啡因和可可碱。黄嘌呤是嘌呤降解途径的产物。随后通过黄嘌呤氧化酶的作用将黄嘌呤转化为尿酸。

[相关活性小分子]

黄嘌呤物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
834.9ºC at 760 mmHg

[ 熔点 ]:
300 °C

[ 分子式 ]:
C₅H₄N₄O₂

[ 分子量 ]:
152.111

[ 闪点 ]:
458.7ºC

[ 精确质量 ]:
152.033432

[ PSA ]:
94.40000

[ LogP ]:
-0.81

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 折射率 ]:
1.636

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
NH4OH: freely soluble

黄嘌呤MSDS

黄嘌呤毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZD7700000

CHEMICAL NAME :: Xanthine

CAS REGISTRY NUMBER :: 69-89-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C5-H4-N4-O2

MOLECULAR WEIGHT :: 152.13

WISWESSER LINE NOTATION :: T56 BM DN FMVMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3333 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3600 mg/kg/18W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 262 umol/L

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,193,1988 *** REVIEWS *** TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3901 No. of Facilities: 68 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 2546 (estimated) No. of Female Employees: 786 (estimated)

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黄嘌呤安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H319

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36;R43

[ 安全声明 (欧洲) ]:
S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
ZD7700000

[ 海关编码 ]:
2933990090

黄嘌呤合成路线

黄嘌呤上下游产品

黄嘌呤上游产品

黄嘌呤下游产品

黄嘌呤制备

由4-氨基-5-甲酰氨基脲嗪与甲酰胺在180-185℃反应而得。

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黄嘌呤海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

黄嘌呤文献

Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats.

Naunyn Schmiedebergs Arch. Pharmacol. 387(9) , 849-59, (2014)

Elevated polyol pathway enzyme activities and oxidative stress play an important role in the development and progression of diabetic nephropathy. Here, we investigated the beneficial influence of nige...

Antioxidant Capacities and Analysis of Phenolic Compounds in Three Endemic Nolana Species by HPLC-PDA-ESI-MS.

Molecules 20 , 11490-507, (2015)

The antioxidant features, polyphenolic composition and chromatographic fingerprints of the aerial parts from three Chilean endemic plants from the Paposo Valley located on the cost of the Atacama Dese...

Spironolactone and dimethylsulfoxide effect on glucose metabolism and oxidative stress markers in polycystic ovarian syndrome rat model.

Exp. Clin. Endocrinol. Diabetes 122(3) , 154-62, (2014)

Because polycystic ovarian syndrome (PCOS) is a risk factor for type 2 diabetes, the affected women can present frequently prediabetic states such as impaired fasting glycaemia and/or impaired glucose...

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黄嘌呤

黄嘌呤用途

黄嘌呤名称

黄嘌呤生物活性

黄嘌呤物理化学性质

黄嘌呤MSDS

详细MSDS(安全技术说明书)

黄嘌呤毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

黄嘌呤安全信息

黄嘌呤合成路线

详细合成路线

黄嘌呤上下游产品

黄嘌呤上游产品

黄嘌呤下游产品

黄嘌呤制备

黄嘌呤海关

黄嘌呤文献

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