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D-(+)-苹果酸

D-(+)-苹果酸用途

D-(+)-Malic acid (D-Malic acid) 是Malic acid 一个活性异构体,是 L(--)malic acid 转运的竞争性抑制剂。

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D-(+)-苹果酸名称

[ CAS 号 ]:
636-61-3

[ 中文名 ]:
D-(+)-苹果酸

[ 英文名 ]:
D-(+)-Malic acid

[中文别名 ]:

[英文别名 ]:

Malic acid, D-
(R)-Hydroxybutanedioic acid
Butanedioic acid, 2-hydroxy-, (2R)-
EINECS 211-262-2
(R)-(+)-HYDROXYSUCCINIC ACID
Malic acid,D
R-Malic acid
D-malate
D-Malic Acid
(R)-2-Hydroxysuccinic acid

D-(+)-苹果酸生物活性

[ 描述 ]:

D-(+)-Malic acid (D-Malic acid) 是Malic acid 一个活性异构体,是 L(--)malic acid 转运的竞争性抑制剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[体外研究]

一些属于节杆菌、短杆菌、棒状杆菌、假单胞菌、芽孢杆菌和不动杆菌的细菌在含有0.1%氯化钠的pH7.0磷酸盐缓冲液中与马来酸发生需氧反应时,从马来酸中产生D-(+)-苹果酸(D-苹果酸)[2]。

[参考文献]

[1]. Manuela Côrte-Real, et al. Transport of L(-)malic acid and other dicarboxylic acids in the yeast Candida sphaerica. Appl Microbiol Biotechnol (1989) 31:551-555.

[2]. Kiyoshi Nakayama, et al. D-malic acid production from maleic acid using microorganism: Screening of microorganism. Biotechnology Letters volume 15, 271–276(1993).

D-(+)-苹果酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
306.4±27.0 °C at 760 mmHg

[ 熔点 ]:
98-104ºC

[ 分子式 ]:
C₄H₆O₅

[ 分子量 ]:
134.087

[ 闪点 ]:
153.4±20.2 °C

[ 精确质量 ]:
134.021530

[ PSA ]:
94.83000

[ LogP ]:
-1.26

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.529

[ 储存条件 ]:
室温

D-(+)-苹果酸MSDS

D-(+)-苹果酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON7260000

CHEMICAL NAME :: Malic acid, L(+)-

CAS REGISTRY NUMBER :: 636-61-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H6-O5

MOLECULAR WEIGHT :: 134.10

WISWESSER LINE NOTATION :: QVYQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL. Volume(issue)/page/year: 15,628,1923

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D-(+)-苹果酸安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
ON7260000

[ 海关编码 ]:
29181980

D-(+)-苹果酸合成路线

D-(+)-苹果酸上下游产品

D-(+)-苹果酸上游产品

D-(+)-苹果酸下游产品

D-(+)-苹果酸制备

1. 从不成熟的苹果中单离出苹果酸；工业上主要用苯经催化氧化生成顺丁烯二酸酐，然后再高温高压下与水反应制取。

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D-(+)-苹果酸海关

[ 海关编码 ]: 2918199090

[ 中文概述 ]:
HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

D-(+)-苹果酸文献

GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy.

Am. J. Physiol. Renal Physiol. 304(11) , F1317-24, (2013)

Early diagnosis of diabetic nephropathy (DN) is difficult although it is of crucial importance to prevent its development. To probe potential markers and the underlying mechanism of DN, an animal mode...

In vitro reactive oxygen species production by mitochondria from the rabbitfish Siganus fuscessens livers and the effects of Irgarol-1051.

Environ. Toxicol. Pharmacol. 35(2) , 154-60, (2013)

In this study, the mitochondria from the livers of Siganus fuscessens were exposed to the Irgarol-1051with or without respiratory chain inhibitors using succinate or malate as the substrate, and the e...

Changes in pH and organic acids in mucilage of Eriophorum angustifolium roots after exposure to elevated concentrations of toxic elements.

Environ. Sci. Pollut. Res. Int. 20(3) , 1876-80, (2013)

The presence of Eriophorum angustifolium in mine tailings of pyrite maintains a neutral pH, despite weathering, thus lowering the release of toxic elements into acid mine drainage water. We investigat...

更多文献

D-(+)-苹果酸

D-(+)-苹果酸用途

D-(+)-苹果酸名称

D-(+)-苹果酸生物活性

D-(+)-苹果酸物理化学性质

D-(+)-苹果酸MSDS

详细MSDS(安全技术说明书)

D-(+)-苹果酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

D-(+)-苹果酸安全信息

D-(+)-苹果酸合成路线

详细合成路线

D-(+)-苹果酸上下游产品

D-(+)-苹果酸上游产品

D-(+)-苹果酸下游产品

D-(+)-苹果酸制备

D-(+)-苹果酸海关

D-(+)-苹果酸文献

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