< 生产厂家 价格 >

羧甲司坦

羧甲司坦用途

Carbocisteine 是一种粘液溶解剂,可用于慢性阻塞性肺疾病 (COPD) 的研究。
点击显示

羧甲司坦名称

[ CAS 号 ]:
638-23-3

[ 中文名 ]:
羧甲司坦

[ 英文名 ]:
Carbocisteine

[中文别名 ]:

[英文别名 ]:

羧甲司坦生物活性

[ 描述 ]:

Carbocisteine 是一种粘液溶解剂,可用于慢性阻塞性肺疾病 (COPD) 的研究。

[ 相关类别 ]:

研究领域 >> 感染
信号通路 >> 其他 >> 其他
研究领域 >> 炎症/免疫

[参考文献]

[1]. Paola Rogliani, et al. Efficacy and safety profile of mucolytic/antioxidant agents in chronic obstructive pulmonary disease: a comparative analysis across erdosteine, carbocysteine, and N-acetylcysteine. Respir Res. 2019 May 27;20(1):104.

羧甲司坦物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
417.3±45.0 °C at 760 mmHg

[ 熔点 ]:
208-213 °C (dec.)

[ 分子式 ]:
C5H9NO4S

[ 分子量 ]:
179.194

[ 闪点 ]:
206.2±28.7 °C

[ 精确质量 ]:
179.025223

[ PSA ]:
125.92000

[ LogP ]:
0.32

[ 外观性状 ]:
白色至略灰白色非晶形的粉末

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.588

[ 储存条件 ]:
库房低温通风干燥

[ 水溶解性 ]:
SOLUBLE IN COLD WATER

羧甲司坦MSDS

详细MSDS(安全技术说明书)

羧甲司坦毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY4342000
CHEMICAL NAME :
Alanine, 3-((carboxymethyl)thio)-, L-
CAS REGISTRY NUMBER :
638-23-3
BEILSTEIN REFERENCE NO. :
1725012
LAST UPDATED :
199707
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C5-H9-N-O4-S
MOLECULAR WEIGHT :
179.21
WISWESSER LINE NOTATION :
QVYZ1S1VQ -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 24,1705,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,190,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10300 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 32,993,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,190,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1433 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 94,1419,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,190,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11250 mg/kg/30D-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 32,993,1981 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
625 mg/kg
SEX/DURATION :
female 17-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,1311,1979
点击显示

羧甲司坦安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
AY4342000

[ 海关编码 ]:
2930909090

羧甲司坦合成路线

详细合成路线

羧甲司坦上下游产品

羧甲司坦上游产品

羧甲司坦下游产品

羧甲司坦制备

L-半胱氨酸配制成二钠盐水溶液，与氯乙酸在焦亚硫酸钠存在下反应，先在20-30℃反应0.5h，再于20℃反应15min，向反应物中加入活性炭，过滤，滤液用浓盐酸酸化至pH2.5，即生成羧甲司坦沉淀，过滤，水洗，真空干燥，即得成品。以L-半胱氨酸计，收率92%。

点击显示

羧甲司坦海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

羧甲司坦文献

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.

Toxicol. Mech. Methods 18 , 217-27, (2008)

ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifes...

Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.

Bioorg. Med. Chem. Lett. 17 , 3921-4, (2007)

Inhibition of Eg5 represents a novel approach for the treatment of cancer. Here, we report the synthesis and structure-activity relationship of S-trityl-L-cysteine (STLC) derivatives as Eg5 inhibitors...


更多文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：L-3-(羧甲基硫代)丙氨酸

公司名：南通润丰石油化工有限公司

区域：南通市崇川区

价格：
￥需询单/1kg ￥需询单/1ton

联系人：曹经理

产品详情：羧甲基半胱氨酸

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥108.0/1g ￥178.0/5g

联系人：刘佳

产品详情：S-羧甲基-L-半胱氨酸

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥689.0/100mg

联系人：李先生

产品详情：羧甲司坦

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥279.9/100g ￥39.9/1g ￥115.9/25g ￥52.9/5g

联系人：阿拉丁

产品详情：S-(羧甲基)-L-半胱氨酸

查看所有供应商请点击：

羧甲司坦供应商

相关化合物

【羧甲司坦】化源网提供羧甲司坦CAS号638-23-3，羧甲司坦MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询羧甲司坦上化源网，专业又轻松。>>电脑版：羧甲司坦

标题：羧甲司坦_MSDS_用途_密度_羧甲司坦CAS号【638-23-3】_化源网 地址：https://m.chemsrc.com/mip/cas/638-23-3_946689.html