异麦芽酮糖醇

异麦芽酮糖醇用途

Isomalt (Palatinitol) 是一种耐受性良好,无毒的多元醇和蛋白质稳定的赋形剂,在冷冻干燥过程中可适度稳定乳酸脱氢酶 (LDH),并在储存期间表现更好。 Isomalt 传统上在食品工业中用作甜味剂,并在制药中用作压片赋形剂。

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异麦芽酮糖醇名称

[ CAS 号 ]:
64519-82-0

[ 中文名 ]:
异麦芽酮糖醇

[ 英文名 ]:
glucosylmannitol

[中文别名 ]:

益寿糖

[英文别名 ]:

1-O-α-D-Glucopyranosyl-D-mannitol
Plaltinitol
PALATINOL
ISOMALT USP
MFCD00190708
PALATINIT
hydrogenated isomaltulose
glucosylmannitol
Isomaltitol
EINECS 203-252-1

异麦芽酮糖醇生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 乳酸脱氢酶

研究领域 >> 代谢疾病

[体内研究]

研究了口服异麦芽作为饲料的一部分对动物的慢性毒性,发现异麦芽是一种安全的物质。它没有影响动物的死亡率,也没有致癌或对生育、生殖性能或发育产生不利影响的证据[1]。

[参考文献]

[1]. Tuderman AK, et al. Isomalt and its diastereomer mixtures as stabilizing excipients with freeze-dried lactate dehydrogenase. Int J Pharm. 2018 Mar 1;538(1-2):287-295.

异麦芽酮糖醇物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
788.5±60.0 °C at 760 mmHg

[ 熔点 ]:
215-217°C

[ 分子式 ]:
C₁₂H₂₄O₁₁

[ 分子量 ]:
344.312

[ 闪点 ]:
430.7±32.9 °C

[ 精确质量 ]:
344.131866

[ PSA ]:
401.06000

[ LogP ]:
-5.72

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±6.2 mmHg at 25°C

[ 折射率 ]:
1.634

[ 储存条件 ]:
2-8°C

异麦芽酮糖醇MSDS

详细MSDS(安全技术说明书)

异麦芽酮糖醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4394500

CHEMICAL NAME :: D-Glucitol, 6-O-alpha-D-glucopyranosyl-, mixed with 1-O-alpha-D-glucopyranosyl-D-mannitol

CAS REGISTRY NUMBER :: 64519-82-0

LAST UPDATED :: 199312

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H24-O11.C12-H24-O11

MOLECULAR WEIGHT :: 688.72

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 125 mg/kg

SEX/DURATION :: female 5 day(s) pre-mating female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 27,631,1989

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异麦芽酮糖醇安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
22-26-36/37/39-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
LZ4394500

[ 海关编码 ]:
2940000000

异麦芽酮糖醇制备

由蔗糖用酶法转化为异麦芽酮糖（帕拉金糖）后，催化加氢，经浓缩、结晶、分离而得。

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异麦芽酮糖醇海关

[ 海关编码 ]: 2940000000

异麦芽酮糖醇文献

Assessment of isomalt for colon-specific delivery and its comparison with lactulose.

AAPS PharmSciTech 14(1) , 53-9, (2013)

Lactulose is used as a triggering substance in a unique colon-specific delivery technology called CODESTM. Colonic microflora degrades lactulose and forms short-chain fatty acids to activate the CODES...

Effect of isomalt consumption on faecal microflora and colonic metabolism in healthy volunteers.

Br. J. Nutr. 95(1) , 40-50, (2006)

Due to its low digestibility in the small intestine, a major fraction of the polyol isomalt reaches the colon. However, little is known about effects on the intestinal microflora. During two 4-week pe...

Effects of isomalt consumption on gastrointestinal and metabolic parameters in healthy volunteers.

Br. J. Nutr. 94(4) , 575-81, (2005)

The polyol isomalt (Palatinit) is a well established sugar replacer. The impact of regular isomalt consumption on metabolism and parameters of gut function in nineteen healthy volunteers was examined ...

更多文献

异麦芽酮糖醇

异麦芽酮糖醇用途

异麦芽酮糖醇名称

异麦芽酮糖醇生物活性

异麦芽酮糖醇物理化学性质

异麦芽酮糖醇MSDS

详细MSDS(安全技术说明书)

异麦芽酮糖醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

异麦芽酮糖醇安全信息

异麦芽酮糖醇制备

异麦芽酮糖醇海关

异麦芽酮糖醇文献

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