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补骨脂素

补骨脂素用途

补骨脂素(呋喃香豆素)是从补骨脂提取的有效成分,具有抗癌活性。

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补骨脂素名称

[ CAS 号 ]:
66-97-7

[ 中文名 ]:
补骨内酯

[ 英文名 ]:
Psoralen

[中文别名 ]:

[英文别名 ]:

Furocoumarin
7H-Furo[3,2-g]chromen-7-one
Psoralen
EINECS 200-639-7
Psoralene
prosuler
6,7-Furanocoumarin
MFCD00010520
Psorline-P
FICUSIN

补骨脂素生物活性

[ 描述 ]:

补骨脂素(呋喃香豆素)是从补骨脂提取的有效成分,具有抗癌活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

天然产物 >> 苯丙酸类

[参考文献]

[1]. Xu K, et al. Psoralen activates cartilaginous cellular functions of rat chondrocytes in vitro. Pharm Biol. 2014 Dec 4:1-6.

[2]. Lu H, et al. Isolation and purification of psoralen and isopsoralen and their efficacy and safety in the treatment of osteosarcoma in nude rats. Afr Health Sci. 2014 Sep;14(3):641-7.

[3]. Wu C, et al. Psoralen inhibits bone metastasis of breast cancer in mice. Fitoterapia. 2013 Dec;91:205-10.

[相关活性小分子]

补骨脂素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
362.6±27.0 °C at 760 mmHg

[ 熔点 ]:
160-162 °C

[ 分子式 ]:
C₁₁H₆O₃

[ 分子量 ]:
186.163

[ 闪点 ]:
173.1±23.7 °C

[ 精确质量 ]:
186.031693

[ PSA ]:
43.35000

[ LogP ]:
1.67

[ 外观性状 ]:
结晶固体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.667

[ 储存条件 ]:
2-8°C

补骨脂素MSDS

补骨脂素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV0944000

CHEMICAL NAME :: 7H-Furo(3,2-g)(1)benzopyran-7-one

CAS REGISTRY NUMBER :: 66-97-7

BEILSTEIN REFERENCE NO. :: 0152784

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C11-H6-O3

MOLECULAR WEIGHT :: 186.17

WISWESSER LINE NOTATION :: T C566 DO LVOJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Gene conversion and mitotic recombination

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 50 umol/L

REFERENCE :: BUCABS Bulletin du Cancer. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1966- Volume(issue)/page/year: 67,245,1980

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补骨脂素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LV0944000

补骨脂素合成路线

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补骨脂素文献

Rotavirus increases levels of lipidated LC3 supporting accumulation of infectious progeny virus without inducing autophagosome formation.

PLoS ONE 9(4) , e95197, (2014)

Replication of many RNA viruses benefits from subversion of the autophagic pathway through many different mechanisms. Rotavirus, the main etiologic agent of pediatric gastroenteritis worldwide, has be...

Inhibition of human aldehyde oxidase activity by diet-derived constituents: structural influence, enzyme-ligand interactions, and clinical relevance.

Drug Metab. Dispos. 43(1) , 34-41, (2014)

The mechanistic understanding of interactions between diet-derived substances and conventional medications in humans is nascent. Most investigations have examined cytochrome P450-mediated interactions...

Assessment of a candidate marker constituent predictive of a dietary substance-drug interaction: case study with grapefruit juice and CYP3A4 drug substrates.

J. Pharmacol. Exp. Ther. 351(3) , 576-84, (2014)

Dietary substances, including herbal products and citrus juices, can perpetrate interactions with conventional medications. Regulatory guidances for dietary substance-drug interaction assessment are l...

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