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氟奋乃静

氟奋乃静用途

氟奋乃静是一种口服有效的吩噻嗪类多巴胺受体拮抗剂。氟奋乃静用于精神分裂症的研究。氟奋乃静阻断神经元电压门控钠通道[1]。
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氟奋乃静名称

[ CAS 号 ]:
69-23-8

[ 中文名 ]:
氟奋乃静

[ 英文名 ]:
Fluphenazine

[中文别名 ]:

[英文别名 ]:

氟奋乃静生物活性

[ 描述 ]:

氟奋乃静是一种口服有效的吩噻嗪类多巴胺受体拮抗剂。氟奋乃静用于精神分裂症的研究。氟奋乃静阻断神经元电压门控钠通道[1]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钠通道
信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
信号通路 >> 神经信号通路 >> 多巴胺受体
研究领域 >> 神经疾病

[参考文献]

[1]. Zhou X, et al. The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels. Brain Res. 2006;1106(1):72-81.

氟奋乃静物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
568.3±50.0 °C at 760 mmHg

[ 熔点 ]:
268-274℃

[ 分子式 ]:
C22H26F3N3OS

[ 分子量 ]:
437.522

[ 闪点 ]:
297.5±30.1 °C

[ 精确质量 ]:
437.174866

[ PSA ]:
55.25000

[ LogP ]:
4.84

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.579

氟奋乃静毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL9730000
CHEMICAL NAME :
1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-
CAS REGISTRY NUMBER :
69-23-8
LAST UPDATED :
199706
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C22-H26-F3-N3-O-S
MOLECULAR WEIGHT :
437.57
WISWESSER LINE NOTATION :
T C666 BN ISJ EXFFF B3- AT6N DNTJ D2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,540,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
640 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Autonomic Nervous System - central sympatholytic Behavioral - alteration of classical conditioning
REFERENCE :
MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 4(2),199,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,540,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
89 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - coma
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 145,450,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
51 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,540,1960 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
62 mg/kg
SEX/DURATION :
female 9 day(s) pre-mating female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
REFERENCE :
APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. (Berlin, Ger.) V.254-263, 1966-69. For publisher information, see NSAPCC. Volume(issue)/page/year: 257,338,1967
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
18 mg/kg
SEX/DURATION :
female 9 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
REFERENCE :
APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. (Berlin, Ger.) V.254-263, 1966-69. For publisher information, see NSAPCC. Volume(issue)/page/year: 257,338,1967 *** REVIEWS *** TOXICOLOGY REVIEW JMSCA9 Journal of Mental Science. (London, UK) V.4-108, 1857-1962. For publisher information, see BJPYAJ. Volume(issue)/page/year: 106,755,1960 TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 1,203,1974
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氟奋乃静安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
16-36/37-45

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

氟奋乃静合成路线

详细合成路线

氟奋乃静制备

由羟乙基哌嗪与溴代氯丙烷经烷基化再与2-三氟甲基吩噻嗪缩合成盐制得。用间三氟甲基苯胺经缩合、消除、环合等亦可制得。
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氟奋乃静文献

Adherence challenges and long-acting injectable antipsychotic treatment in patients with schizophrenia.

J. Psychosoc. Nurs. Ment. Health Serv. 51(3) , 13-8, (2013)

Medication nonadherence has been associated with persistence of psychotic symptoms, relapse, and hospitalization in patients with schizophrenia. Patients with untreated psychosis are significantly les...

Latent inhibition in an insect: the role of aminergic signaling.

Learn. Mem. 19(12) , 593-7, (2012)

Latent inhibition (LI) is a decrement in learning performance that results from the nonreinforced pre-exposure of the to-be-conditioned stimulus, in both vertebrates and invertebrates. In vertebrates,...

[Copper intoxication decreases lifespan and induces neurologic alterations in Drosophila melanogaster].

Invest. Clin. 54(1) , 47-57, (2013)

Wilson disease is a hereditary disorder caused by mutations of the ATP7B gene, which leads to intoxication with copper as a result of an unbalance of copper homeostasis. The clinical manifestations re...


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推荐生产厂家/供应商：

公司名：上海化源生化科技有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：吉他霉素

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Fluphenazine

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥678.9/100mg ￥1409.9/500mg ￥451.9/50mg ￥6921.9/5g

联系人：阿拉丁

产品详情：吉他霉素

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相关化合物

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