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(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐

(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐用途

Sapropterin dihydrochloride是一个合成的BH4形式,被批准用于BH4 反应的 PKU治疗。

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(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐名称

[ CAS 号 ]:
69056-38-8

[ 中文名 ]:
(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐

[ 英文名 ]:
(6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride

[中文别名 ]:

[英文别名 ]:

Dapropterin
(6R)-5,6,7,8-tetrahydro-L-biopterin
(6R)-Tetrahydrobiopterin
6R-tetahydrobiopterin
Dapropterin dihydrochloride
Biopten
sapropterinum
R-THBP
MFCD00891665
(6R)-5,6,7,8-Tetrahydrobiopterin

(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐生物活性

[ 描述 ]:

Sapropterin dihydrochloride是一个合成的BH4形式,被批准用于BH4 反应的 PKU治疗。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 心血管疾病

天然产物 >> 生物碱

[参考文献]

[1]. Winn SR et al. High dose sapropterin dihydrochloride therapy improves monoamine neurotransmitter turnover in murine phenylketonuria (PKU). Mol Genet Metab. 2016 Jan;117(1):5-11.

[2]. Somaraju UR et al. Sapropterin dihydrochloride for phenylketonuria. Cochrane Database Syst Rev. 2015 Mar 27

[3]. Jurecki ER et al. Sapropterin Dihydrochloride Mixed With Common Foods and Beverages. Top Clin Nutr. 2014 Oct;29(4):325-331.

[4]. Grange DK et al. Sapropterin dihydrochloride use in pregnant women with phenylketonuria: an interim report of the PKU MOMS sub-registry. Mol Genet Metab. 2014 May;112(1):9-16

[相关活性小分子]

(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
506.6±60.0 °C at 760 mmHg

[ 分子式 ]:
C₉H₁₇Cl₂N₅O₃

[ 分子量 ]:
314.17

[ 闪点 ]:
260.2±32.9 °C

[ PSA ]:
136.29000

[ LogP ]:
-4.22

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.822

[ 储存条件 ]:
−20°C

(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐MSDS

(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO3516500

CHEMICAL NAME :: 4(1H)-Pteridinone, 5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-, dihydrochloride, (6R-(6R*(1R*,2S*)))-

CAS REGISTRY NUMBER :: 69056-38-8

LAST UPDATED :: 199603

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H15-N5-O3.2Cl-H

MOLECULAR WEIGHT :: 314.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 43,1191,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1084 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 43,1191,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 43,1191,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 43,1191,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 239 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 43,1191,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 43,1191,1992

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(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UO3516500

[ 海关编码 ]:
2933990090

(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐合成路线

(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐上下游产品

(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐上游产品

(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐下游产品

(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐文献

Tetrahydrobiopterin and cytokines.

Proc. Soc. Exp. Biol. Med. 203 , 1, (1993)

Biosynthesis of tetrahydrobiopterin starts from guanosine triphosphate by the action of guanosine triphosphate cyclohydrolase I, which yields the first intermediate, 7,8-dihydroneopterin triphosphate....

Intravenous treatment of experimental Parkinson's disease in the mouse with an IgG-GDNF fusion protein that penetrates the blood-brain barrier.

Brain Res. 1352 , 208-13, (2010)

Glial-derived neurotrophic factor (GDNF) is a trophic factor for the nigra-striatal tract in experimental Parkinson's disease (PD). The neurotrophin must be administered by intra-cerebral injection, b...

A new resorufin-based alpha-glucosidase assay for high-throughput screening.

Anal. Biochem. 390 , 79-84, (2009)

Mutations in alpha-glucosidase cause accumulation of glycogen in lysosomes, resulting in Pompe disease, a lysosomal storage disorder. Small molecule chaperones that bind to enzyme proteins and correct...

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