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L-生物喋呤

L-生物喋呤用途

6-Biopterin (L-Biopterin)，一种蝶呤衍生物，是一氧化氮合酶 (NO synthase) 辅因子。

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L-生物喋呤名称

[ CAS 号 ]:
22150-76-1

[ 中文名 ]:
L-生物蝶呤

[ 英文名 ]:
6-Biopterin

[中文别名 ]:

[英文别名 ]:

D-erythro-Biopterin
biopterin
MFCD00036787
L-Biopterin
Pterin HB2
pterinhb2
(-)-Biopterin
L-Erythro-Biopterin
6-BIOPTERIN
EINECS 244-807-8

L-生物喋呤生物活性

[ 描述 ]:

6-Biopterin (L-Biopterin),一种蝶呤衍生物,是一氧化氮合酶 (NO synthase) 辅因子。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

天然产物 >> 糖和糖苷

研究领域 >> 癌症

研究领域 >> 神经疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

在体外条件下,6-生物蝶呤对人黑素细胞具有极大的细胞毒性。硫氧还蛋白还原酶具有将6-生物蝶呤还原为q-BH2的能力,其中通过二氢蝶啶还原酶或还原型谷胱甘肽进一步还原为6-BH4。 (6R)5,6,7,8四氢生物蝶呤通过连续的两个电子氧化反应氧化成醌类二氢生物喋呤和6-生物喋呤进行氧化还原循环[1]。

[参考文献]

[1]. Schallreuter KU, et al. Cytotoxicity of 6-biopterin to human melanocytes. Biochem Biophys Res Commun. 1994 Oct 14;204(1):43-8.

[相关活性小分子]

L-生物喋呤物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
563.4±60.0 °C at 760 mmHg

[ 熔点 ]:
>210°C dec.

[ 分子式 ]:
C₉H₁₁N₅O₃

[ 分子量 ]:
237.215

[ 闪点 ]:
294.5±32.9 °C

[ 精确质量 ]:
237.086182

[ PSA ]:
138.01000

[ LogP ]:
-3.84

[ 外观性状 ]:
结晶固体

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.822

[ 储存条件 ]:
通风低温干燥

L-生物喋呤MSDS

L-生物喋呤毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO3506000

CHEMICAL NAME :: 4(3H)-Pteridinone, 2-amino-6-(L-erythro-1,2-dihydroxypropyl)-

CAS REGISTRY NUMBER :: 22150-76-1

LAST UPDATED :: 199509

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H11-N5-O3

MOLECULAR WEIGHT :: 237.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 879 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 10 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 128,147,1984

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L-生物喋呤安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UO3506000

[ 海关编码 ]:
2933990090

L-生物喋呤合成路线

L-生物喋呤上下游产品

L-生物喋呤上游产品

L-生物喋呤下游产品

L-生物喋呤海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

L-生物喋呤文献

Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm.

Am. J. Physiol. Heart Circ. Physiol. 307(11) , H1559-64, (2014)

Rupture of abdominal aortic aneurysm (AAA) is unpredictable and lethal. A clinically valid biomarker to monitor the disease has not been available. Based on our recent discoveries that uncoupled endot...

Phenylalanine hydroxylase: function, structure, and regulation.

IUBMB Life 65(4) , 341-9, (2013)

Mammalian phenylalanine hydroxylase (PAH) catalyzes the rate-limiting step in the phenylalanine catabolism, consuming about 75% of the phenylalanine input from the diet and protein catabolism under ph...

Communication between the zinc and tetrahydrobiopterin binding sites in nitric oxide synthase.

Biochemistry 53(25) , 4216-23, (2014)

The nitric oxide synthase (NOS) dimer is stabilized by a Zn(2+) ion coordinated to four symmetry-related Cys residues exactly along the dimer 2-fold axis. Each of the two essential tetrahydrobiopterin...

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