< 生产厂家价格 >

菊苣酸

菊苣酸用途

L-菊苣酸 (L-Chicoric Acid) 是体外HIV-1型病毒整合酶的抑制剂,同时也是该病毒在组织培养复制过程中的抑制剂。

点击显示

菊苣酸名称

[ CAS 号 ]:
70831-56-0

[ 中文名 ]:
菊苣酸

[ 英文名 ]:
Chicoric acid

[中文别名 ]:

紫锥菊提取物

[英文别名 ]:

CICHORINIC ACID
D-Chicoric acid
Cichoric acid
chicoric acid
CHICHORIC ACID
Echinacea Extract
L-CHICORIC ACID
MFCD00189418

菊苣酸生物活性

[ 描述 ]:

L-菊苣酸 (L-Chicoric Acid) 是体外HIV-1型病毒整合酶的抑制剂,同时也是该病毒在组织培养复制过程中的抑制剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 感染

天然产物 >> 苯丙酸类

[参考文献]

[1]. Ryan A Reinke, et al. l-Chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro. Virology Volume 326, Issue 2, 1 September 2004, Pages 203–219

[2]. W Edward Robinson Jr., et al. l-Chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of Zidovudine plus a protease inhibitor (AG1350). Antiviral Research Volume 39, Issue 2, Augu

[3]. King PJ, et al. Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase. Journal of Virology, 1998, 72(10): 8420-8424

[相关活性小分子]

菊苣酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
785.0±60.0 °C at 760 mmHg

[ 熔点 ]:
206 °C

[ 分子式 ]:
C₂₂H₁₈O₁₂

[ 分子量 ]:
474.371

[ 闪点 ]:
272.9±26.4 °C

[ 精确质量 ]:
474.079834

[ PSA ]:
208.12000

[ LogP ]:
3.81

[ 外观性状 ]:
固体;White to Light yellow to Light orange powder to crystal

[ 蒸汽压 ]:
0.0±2.9 mmHg at 25°C

[ 折射率 ]:
1.726

[ 储存条件 ]:
−20°C

菊苣酸MSDS

详细MSDS(安全技术说明书)

菊苣酸安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-42/43

[ 安全声明 (欧洲) ]:
22-36/37-45

[ 危险品运输编码 ]:
NONH for all modes of transport

菊苣酸文献

[Simultaneous determination of five organic acids in Kudiezi injection by HPLC].

Zhongguo Zhong Yao Za Zhi 38(19) , 3287-90, (2013)

The aim was to develop a high performance liquid chromatography method for simultaneous determination of five organic acids in Kudiezi injection. The Diamonsil C18 column (4.6 mm x 200 mm, 5 microm) w...

Application of an online post-column derivatization HPLC-DPPH assay to detect compounds responsible for antioxidant activity in Sonchus oleraceus L. leaf extracts.

J. Pharm. Pharmacol. 65(2) , 271-9, (2013)

To use an online assay to identify key antioxidants in Sonchus oleraceus leaf extracts and to investigate the effect of leaf position and extraction conditions on antioxidant concentration and activit...

Echinacea alkylamides modulate induced immune responses in T-cells.

Fitoterapia 79(1) , 53-8, (2008)

The effects of Echinacea and several of its phytochemical components on NFkappaB expression by Jurkat cells (a human T-cell line) were investigated in vitro. In the absence of stimulation, Echinacea a...

更多文献

菊苣酸