吡咯喹啉醌

吡咯喹啉醌用途

Pyrroloquinoline quinone (PQQ) 是氧化还原辅助因子,一种阴离子型氧化还原循环原醌。Pyrroloquinoline quinone 最初是从嗜甲基细菌的培养物中分离的,也存在于哺乳动物的组织。Pyrroloquinoline quinone 是哺乳动物的必需营养素,对免疫功能很重要。

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吡咯喹啉醌名称

[ CAS 号 ]:
72909-34-3

[ 中文名 ]:
吡咯喹啉醌

[ 英文名 ]:
pyrroloquinoline quinone

[中文别名 ]:

[英文别名 ]:

MFCD00043125
coenzyme PQQ
PQQ Cofactor
Pyrroloquinoline-quinone
methoxanthin
PQQ
Pyrroloquinoline quinone
Methoxatin

吡咯喹啉醌生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

出生于吡咯喹啉醌(PQQ)剥夺母鼠并由其喂养的幼鼠,其免疫反应和脱发、驼背姿势以及易患主动脉瘤[2]。

[参考文献]

[1]. Moog RS, et al. Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8435-9.

[2]. Bishop A, et al. Methoxatin (PQQ) in guinea-pig neutrophils. Free Radic Biol Med. 1994 Oct;17(4):311-20.

吡咯喹啉醌物理化学性质

[ 密度 ]:
2.0±0.1 g/cm3

[ 沸点 ]:
1018.6±65.0 °C at 760 mmHg

[ 分子式 ]:
C₁₄H₆N₂O₈

[ 分子量 ]:
330.206

[ 闪点 ]:
569.8±34.3 °C

[ 精确质量 ]:
330.012421

[ PSA ]:
174.72000

[ LogP ]:
-0.65

[ 外观性状 ]:
红色到深红色固体

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.801

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Light and Temperature Sensitive

吡咯喹啉醌安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

吡咯喹啉醌合成路线

详细合成路线

吡咯喹啉醌上下游产品

吡咯喹啉醌上游产品

吡咯喹啉醌下游产品

吡咯喹啉醌海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吡咯喹啉醌文献

Molecular-level characterization of elastin-like constructs and human aortic elastin

Matrix Biol. 38 , 12-21, (2014)

This study aimed to characterize the structures of two elastin-like constructs, one composed of a cross-linked elastin-like polypeptide and the other one of cross-linked tropoelastin, and native aorti...

Genome-wide RNA sequencing analysis of quorum sensing-controlled regulons in the plant-associated Burkholderia glumae PG1 strain.

Appl. Environ. Microbiol. 81 , 7993-8007, (2015)

Burkholderia glumae PG1 is a soil-associated motile plant-pathogenic bacterium possessing a cell density-dependent regulation system called quorum sensing (QS). Its genome contains three genes, here d...

Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice.

PLoS ONE 10(3) , e0121939, (2015)

Liver fibrosis represents the consequences of a sustained wound healing response to chronic liver injuries, and its progression toward cirrhosis is the major cause of liver-related morbidity and morta...

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