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碘普罗胺

碘普罗胺用途

Iopromide是用于血管内给药的水溶的低渗透非离子型X射线造影剂。

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碘普罗胺名称

[ CAS 号 ]:
73334-07-3

[ 中文名 ]:
碘普罗胺

[ 英文名 ]:
iopromide

[中文别名 ]:

[英文别名 ]:

iopromide
Ultravist
iopromida
iopromidum
EINECS 277-385-9
Ultravist 300
Ultravist 370
UNII:712BAC33MZ
SHL 414C
MFCD00867924

碘普罗胺生物活性

[ 描述 ]:

Iopromide是用于血管内给药的水溶的低渗透非离子型X射线造影剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 心血管疾病

[体内研究]

尾静脉注射碘普罗胺可诱导造影剂中引起的肾病[1]。在随机对照试验中,iobitridol的全球图像质量和诊断质量与其他低渗造影剂(碘海醇,碘普罗胺,碘帕醇,碘美普尔和异恶唑)或等渗造影剂碘克沙醇在成人或儿童中的差异无统计学差异射线照相成像。大型上市后监测研究证实,iobitridol可产生良好或极好的混浊,是绝大多数患者的有效造影剂。碘比特醇通常具有良好的耐受性,并且具有与其他低渗和等渗对比剂相似的耐受性特征。因此,iobitridol是一种有效的血管内药物,用于诊断成像中的对比度增强[2]。

[动物实验]

小鼠：雄性C57 / BL6J小鼠随机分为7组：对照组，糖尿病组（D），CIN，糖尿病+ CIN（DC），糖尿病+灯盏花素（DB），CIN +灯盏花素（CIN + B）和糖尿病mellitus + CIN +灯盏花素（DCB）。在建立糖尿病模型后，禁止小鼠饮水一晚，然后在1分钟内通过尾静脉给药以10mL / kg碘普罗胺的剂量注射小鼠。然后用或不用灯盏花素（10mg / kg / d）对小鼠进行胃内治疗4周。除灯盏花素处理组（DB，DCB和CIN + B）之外的其他小鼠组在胃内给予相同体积的磷酸盐缓冲溶液4周。然后通过腹膜内注射水合氯醛处死小鼠[1]。

[参考文献]

[1]. Jiang W, et al. Breviscapine attenuatted contrast medium-induced nephropathy via PKC/Akt/MAPK signalling in diabetic mice. Am J Transl Res. 2016 Feb 15;8(2):329-41.

[2]. McCormack PL, et al. Iobitridol: a review of its use as a contrast medium in diagnostic imaging. Clin Drug Investig. 2013 Feb;33(2):155-66.

[相关活性小分子]

碘普罗胺物理化学性质

[ 密度 ]:
2.2±0.1 g/cm3

[ 沸点 ]:
840.9±65.0 °C at 760 mmHg

[ 熔点 ]:
broad (160ºC transition)

[ 分子式 ]:
C₁₈H₂₄I₃N₃O₈

[ 分子量 ]:
791.112

[ 闪点 ]:
462.4±34.3 °C

[ 精确质量 ]:
790.869690

[ PSA ]:
168.66000

[ LogP ]:
-2.95

[ 外观性状 ]:
灰白色至白色粉末

[ 蒸汽压 ]:
0.0±3.3 mmHg at 25°C

[ 折射率 ]:
1.710

[ 储存条件 ]:
Hygroscopic, -20?C Freezer, Under Inert Atmosphere

[ 稳定性 ]:
Hygroscopic

碘普罗胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ2230000

CHEMICAL NAME :: 1,3-Benzenedicarboxamide, N,N'-bis(2,3-dihydroxypropyl)-5-((methoxyacetyl)amino )-N-methyl- 2,4,6-triiodo-

CAS REGISTRY NUMBER :: 73334-07-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C18-H24-I3-N3-O8

MOLECULAR WEIGHT :: 791.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21403 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 370,41,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AAJNDL AJNR, American Journal of Neuroradiology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1980- Volume(issue)/page/year: 4,350,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >21 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 44,1275,1994

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碘普罗胺安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H410

[ 警示性声明 ]:
P273-P501

[ 危害码 (欧洲) ]:
N

[ 风险声明 (欧洲) ]:
50/53

[ 安全声明 (欧洲) ]:
60-61

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
CZ2230000

[ 海关编码 ]:
2924299090

碘普罗胺合成路线

详细合成路线

碘普罗胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

碘普罗胺文献

Adverse skin reactions to iodinated x-ray contrast agents in healthy rats.

Invest. Radiol. 49(12) , 779-87, (2014)

The aim of this preclinical study on healthy Sprague-Dawley rats was to determine whether differences exist in the induction of adverse skin reactions after the intravenous administration of a monomer...

Analysis of the roles of glucose transporter 1 and hexokinase 2 in the metabolism of glucose by extrahepatic bile duct cancer cells.

Clin. Nucl. Med. 40(3) , e178-82, (2015)

Extrahepatic bile duct (EHD) cancer varies in uptake of FDG. The aim of the present study was to determine the role of glucose transporter (GLUT) 1 and hexokinase (HK) 2 in the glucose metabolism of E...

Ventilation/perfusion mismatch during lung aeration at birth.

J. Appl. Physiol. 117(5) , 535-43, (2014)

At birth, the transition to newborn life is triggered by lung aeration, which stimulates a large increase in pulmonary blood flow (PBF). Current theories predict that the increase in PBF is spatially ...

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