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芳樟醇

芳樟醇用途

Linalool 是一种天然单萜类化合物,存在芫荽等植物中,为竞争性的 NMDA 受体拮抗剂,具有抗肿瘤、抗心脏毒性的作用。
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芳樟醇作用

1. 芳樟醇是精油的天然化合物，已被证明具有抗伤害，抗菌和抗炎作用。
2.通过Nrf2激活诱导抗氧化防御并通过NF-κB抑制减少炎症反应，芳樟醇被保护免受LPS / GalN诱导的肝损伤。
3.芳樟醇的生物合成和积累可能参与植物对细菌和真菌病原体的防御，并与柑橘溃疡病的田间抗性有关。
4.芳樟醇显着增加Nrf-2调节的抗氧化酶的表达，并减少几种促炎细胞因子的肺组织水平，包括肿瘤坏死因子α（TNF-α）和白细胞介素（IL）-6。
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芳樟醇名称

[ CAS 号 ]:
78-70-6

[ 中文名 ]:
芳樟醇

[ 英文名 ]:
Linalool

[中文别名 ]:

[英文别名 ]:

芳樟醇生物活性

[ 描述 ]:

Linalool 是一种天然单萜类化合物,存在芫荽等植物中,为竞争性的 NMDA 受体拮抗剂,具有抗肿瘤、抗心脏毒性的作用。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR
研究领域 >> 癌症
研究领域 >> 心血管疾病
信号通路 >> 跨膜转运 >> iGluR

[参考文献]

[1]. Oner Z1, et al. The protective and therapeutic effects of linalool against doxorubicin-induced cardiotoxicity in Wistar albino rats. Hum Exp Toxicol. 2019 Apr 12:960327119842634.

芳樟醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
198.5±0.0 °C at 760 mmHg

[ 分子式 ]:
C10H18O

[ 分子量 ]:
154.25

[ 闪点 ]:
76.1±0.0 °C

[ 精确质量 ]:
154.135757

[ PSA ]:
20.23000

[ LogP ]:
3.28

[ 外观性状 ]:
液体

[ 蒸汽压 ]:
0.1±0.8 mmHg at 25°C

[ 折射率 ]:
1.463

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Combustible.

[ 水溶解性 ]:
1.45 g/L (25 ºC)

芳樟醇MSDS

详细MSDS(安全技术说明书)

芳樟醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RG5775000
CHEMICAL NAME :
1,6-Octadien-3-ol, 3,7-dimethyl-
CAS REGISTRY NUMBER :
78-70-6
BEILSTEIN REFERENCE NO. :
1721488
LAST UPDATED :
199806
DATA ITEMS CITED :
18
MOLECULAR FORMULA :
C10-H18-O
MOLECULAR WEIGHT :
154.28
WISWESSER LINE NOTATION :
1U1XQ1&3UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human - man
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2790 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5610 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
307 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
340 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1470 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5610 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA repair
TEST SYSTEM :
Bacteria - Bacillus subtilis
DOSE/DURATION :
8622 ug/disc
REFERENCE :
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975- Volume(issue)/page/year: 34,267,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4982 No. of Facilities: 37 (estimated) No. of Industries: 2 No. of Occupations: 16 No. of Employees: 2301 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4982 No. of Facilities: 16058 (estimated) No. of Industries: 106 No. of Occupations: 118 No. of Employees: 245476 (estimated) No. of Female Employees: 109311 (estimated)
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芳樟醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319

[ 警示性声明 ]:
P280-P305 + P351 + P338-P337 + P313

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NA 1993 / PGIII

[ WGK德国 ]:
1

[ RTECS号 ]:
RG5775000

[ 海关编码 ]:
2905223000

芳樟醇合成路线

详细合成路线

芳樟醇上下游产品

芳樟醇上游产品

芳樟醇下游产品

芳樟醇制备

1、醇存在于多种精油中。目前制取芳樟醇的主要方法有两种，一种是从芳樟油等植物精油中分离而得，得到的主要是左旋异构体；另一种方法是通过蒎烯来制备。

2、烟草：BU，56；BU，14；FC，BU，OR，18；FC，40。合成：从天然精油中单离；月桂烯与氯化氢反应，生成氯代月桂烯，经水解生成芳樟醇；异戊二烯与氯化氢生成氯代异戊烯，然后与丙酮作用生成甲基庚烯酮，与乙炔反应生成脱氢芳樟醇，最后经氢化制成芳樟醇。
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芳樟醇海关

[ 海关编码 ]: 2905223000

[ 中文概述 ]:
2905223000. 芳樟醇. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最低关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2905223000. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:5.5%. General tariff:30.0%

芳樟醇文献

Identification of odorants in frankincense (Boswellia sacra Flueck.) by aroma extract dilution analysis and two-dimensional gas chromatography-mass spectrometry/olfactometry.

Phytochemistry 109 , 66-75, (2014)

Frankincense has been known, traded and used throughout the ages for its exceptional aroma properties, and is still commonly used in both secular and religious settings to convey a pleasant odor. Surp...

Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.

Antimicrob. Agents Chemother. 53 , 1898-906, (2009)

Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have sho...

Volatile Compounds from Grape Skin, Juice and Wine from Five Interspecific Hybrid Grape Cultivars Grown in Québec (Canada) for Wine Production.

Molecules 20 , 10980-1016, (2015)

Developed from crosses between Vitis vinifera and North American Vitis species, interspecific hybrid grape varieties are becoming economically significant in northern areas, where they are now extensi...


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产品详情：芳樟醇

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相关化合物

【芳樟醇】化源网提供芳樟醇CAS号78-70-6，芳樟醇MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询芳樟醇上化源网，专业又轻松。>>电脑版：芳樟醇

标题：芳樟醇_MSDS_作用_用途_芳樟醇CAS号【78-70-6】_化源网 地址：https://m.chemsrc.com/mip/cas/78-70-6_663193.html