芳樟醇

芳樟醇用途

Linalool 是一种天然单萜类化合物,存在芫荽等植物中,为竞争性的 NMDA 受体拮抗剂,具有抗肿瘤、抗心脏毒性的作用。

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芳樟醇作用

1. 芳樟醇是精油的天然化合物，已被证明具有抗伤害，抗菌和抗炎作用。
2.通过Nrf2激活诱导抗氧化防御并通过NF-κB抑制减少炎症反应，芳樟醇被保护免受LPS / GalN诱导的肝损伤。
3.芳樟醇的生物合成和积累可能参与植物对细菌和真菌病原体的防御，并与柑橘溃疡病的田间抗性有关。
4.芳樟醇显着增加Nrf-2调节的抗氧化酶的表达，并减少几种促炎细胞因子的肺组织水平，包括肿瘤坏死因子α（TNF-α）和白细胞介素（IL）-6。

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芳樟醇名称

[ CAS 号 ]:
78-70-6

[ 中文名 ]:
芳樟醇

[ 英文名 ]:
Linalool

[中文别名 ]:

[英文别名 ]:

3,7-Dimethylocta-1,6-dien-3-ol
MFCD02114395
allo-Ocimenol
Linanool
1,6-Octadien-3-ol, 3,7-dimethyl-
dl-Linalool
3,7-dimethyloct-1,6-dien-3-ol
(±)-Linalool
Linolool
Linalool

芳樟醇生物活性

[ 描述 ]:

Linalool 是一种天然单萜类化合物,存在芫荽等植物中,为竞争性的 NMDA 受体拮抗剂,具有抗肿瘤、抗心脏毒性的作用。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 癌症

研究领域 >> 心血管疾病

信号通路 >> 跨膜转运 >> iGluR

[参考文献]

[1]. Oner Z1, et al. The protective and therapeutic effects of linalool against doxorubicin-induced cardiotoxicity in Wistar albino rats. Hum Exp Toxicol. 2019 Apr 12:960327119842634.

芳樟醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
198.5±0.0 °C at 760 mmHg

[ 分子式 ]:
C₁₀H₁₈O

[ 分子量 ]:
154.25

[ 闪点 ]:
76.1±0.0 °C

[ 精确质量 ]:
154.135757

[ PSA ]:
20.23000

[ LogP ]:
3.28

[ 外观性状 ]:
液体

[ 蒸汽压 ]:
0.1±0.8 mmHg at 25°C

[ 折射率 ]:
1.463

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Combustible.

[ 水溶解性 ]:
1.45 g/L (25 ºC)

芳樟醇MSDS

详细MSDS(安全技术说明书)

芳樟醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RG5775000

CHEMICAL NAME :: 1,6-Octadien-3-ol, 3,7-dimethyl-

CAS REGISTRY NUMBER :: 78-70-6

BEILSTEIN REFERENCE NO. :: 1721488

LAST UPDATED :: 199806

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C10-H18-O

MOLECULAR WEIGHT :: 154.28

WISWESSER LINE NOTATION :: 1U1XQ1&3UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human - man

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2790 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5610 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 307 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 340 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1470 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5610 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 8622 ug/disc

REFERENCE :: OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975- Volume(issue)/page/year: 34,267,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4982 No. of Facilities: 37 (estimated) No. of Industries: 2 No. of Occupations: 16 No. of Employees: 2301 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4982 No. of Facilities: 16058 (estimated) No. of Industries: 106 No. of Occupations: 118 No. of Employees: 245476 (estimated) No. of Female Employees: 109311 (estimated)

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芳樟醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319

[ 警示性声明 ]:
P280-P305 + P351 + P338-P337 + P313

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NA 1993 / PGIII

[ WGK德国 ]:
1

[ RTECS号 ]:
RG5775000

[ 海关编码 ]:
2905223000

芳樟醇合成路线

详细合成路线

芳樟醇上下游产品

芳樟醇上游产品

芳樟醇下游产品

芳樟醇制备

1、醇存在于多种精油中。目前制取芳樟醇的主要方法有两种，一种是从芳樟油等植物精油中分离而得，得到的主要是左旋异构体；另一种方法是通过蒎烯来制备。

2、烟草：BU，56；BU，14；FC，BU，OR，18；FC，40。合成：从天然精油中单离；月桂烯与氯化氢反应，生成氯代月桂烯，经水解生成芳樟醇；异戊二烯与氯化氢生成氯代异戊烯，然后与丙酮作用生成甲基庚烯酮，与乙炔反应生成脱氢芳樟醇，最后经氢化制成芳樟醇。

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芳樟醇海关

[ 海关编码 ]: 2905223000

[ 中文概述 ]:
2905223000. 芳樟醇. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最低关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2905223000. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:5.5%. General tariff:30.0%

芳樟醇文献

Identification of odorants in frankincense (Boswellia sacra Flueck.) by aroma extract dilution analysis and two-dimensional gas chromatography-mass spectrometry/olfactometry.

Phytochemistry 109 , 66-75, (2014)

Frankincense has been known, traded and used throughout the ages for its exceptional aroma properties, and is still commonly used in both secular and religious settings to convey a pleasant odor. Surp...

Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.

Antimicrob. Agents Chemother. 53 , 1898-906, (2009)

Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have sho...

Volatile Compounds from Grape Skin, Juice and Wine from Five Interspecific Hybrid Grape Cultivars Grown in Québec (Canada) for Wine Production.

Molecules 20 , 10980-1016, (2015)

Developed from crosses between Vitis vinifera and North American Vitis species, interspecific hybrid grape varieties are becoming economically significant in northern areas, where they are now extensi...

更多文献

芳樟醇

芳樟醇用途

芳樟醇作用

芳樟醇名称

芳樟醇生物活性

芳樟醇物理化学性质

芳樟醇MSDS

详细MSDS(安全技术说明书)

芳樟醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

芳樟醇安全信息

芳樟醇合成路线

详细合成路线

芳樟醇上下游产品

芳樟醇上游产品

芳樟醇下游产品

芳樟醇制备

芳樟醇海关

芳樟醇文献

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