冈田(软海绵)酸

冈田(软海绵)酸用途

Okadaic acid 是从 Halichondria 属的黑色海绵中提取的。Okadaic acid 是一种非竞争性,选择性和可逆的丝氨酸/苏氨酸特异性蛋白磷酸酶 1 (PP1),PP2A 和 PP3 的抑制剂,IC50 分别为 10-15 nM,0.5 nM 和 4 nM。Okadaic acid 通过细胞凋亡消除后生共生体/寄生虫。

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冈田(软海绵)酸名称

[ CAS 号 ]:
78111-17-8

[ 中文名 ]:
冈田(软海绵)酸

[ 英文名 ]:
Okadaic acid

[中文别名 ]:

[英文别名 ]:

Halochondrine A
Okadic acid
9,10-deepithio-9,10-didehydroacanthifolicin
okadaic acd
MFCD00083455
Okadaic acid
OKADAICACID,HIGHPURITY
Ocadaic Acid

冈田(软海绵)酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶

研究领域 >> 感染

[ 靶点 ]

IC50: 10-15 nM (PP1), 0.5 nM (PP2) and 4 nM (PP3)[1]

[参考文献]

[1]. Bialojan C, et al. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics. Biochem J. 1988 Nov 15;256(1):283-90.

[2]. McCluskey A, et al. Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem. 2002 Mar 14;45(6):1151-75.

[3]. Schröder HC, et al. Okadaic acid, an apoptogenic toxin for symbiotic/parasitic annelids in the demosponge Suberites domuncula. Appl Environ Microbiol. 2006 Jul;72(7):4907-16.

冈田(软海绵)酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
921.6±65.0 °C at 760 mmHg

[ 熔点 ]:
164-166ºC

[ 分子式 ]:
C₄₄H₆₈O₁₃

[ 分子量 ]:
805.003

[ 闪点 ]:
269.4±27.8 °C

[ 精确质量 ]:
804.466003

[ PSA ]:
182.83000

[ LogP ]:
4.21

[ 外观性状 ]:
白色晶体或粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.585

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

冈田(软海绵)酸MSDS

冈田(软海绵)酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AA8227800

CHEMICAL NAME :: Acanthifolicin, 9,10-deepithio-9,10-didehydro-

CAS REGISTRY NUMBER :: 78111-17-8

LAST UPDATED :: 199403

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C44-H68-O13

MOLECULAR WEIGHT :: 805.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 192 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 mg/kg/30W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 250,375,1991

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冈田(软海绵)酸安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H315

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P261-P280-P302 + P352 + P312-P304 + P340 + P312-P403 + P233

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S26;S45;S36/S37

[ 危险品运输编码 ]:
UN 3462 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
AA8227800

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
29321900

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冈田(软海绵)酸文献

Uptake of neutrophil-derived Ym1 protein distinguishes wound macrophages in the absence of interleukin-4 signaling in murine wound healing.

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The determination of regenerative wound-healing macrophages as alternatively activated macrophages is currently questioned by the absence of IL-4 in wound tissue. Yet, murine wound tissue expressed hi...

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During mitosis, the spindle checkpoint senses kinetochores not properly attached to spindle microtubules and prevents precocious sister-chromatid separation and aneuploidy. The constitutive centromere...

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The 26S proteasome is the primary machinery that degrades ubiquitin (Ub)-conjugated proteins, including many proteotoxic proteins implicated in neurodegeneraton. It has been suggested that the elevati...

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