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LP-44

LP-44用途

LP44(盐酸盐)是一种选择性5-HT7激动剂,Ki为0.22 nM。LP44(盐酸盐)通过侧脑室注射以剂量依赖性方式诱导低温效应。LP44(盐酸盐)腹腔注射不会引起明显的低温反应[1]。

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LP-44名称

[ CAS 号 ]:
824958-12-5

[ 英文名 ]:
LP-44

[英文别名 ]:

Psalmotoxin 1
LP44,hydrochloride

LP-44生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

[体内研究]

LP44(盐酸盐)(5.1、10.3、20.5、41.0 nmol；i.c.v.)在CBA小鼠中产生剂量依赖性低温效应【1】。

[参考文献]

[1]. Naumenko VS,et al. On the role of brain 5-HT7 receptor in the mechanism of hypothermia: comparison with hypothermia mediated via 5-HT1A and 5-HT3 receptor. Neuropharmacology. 2011 Dec;61(8):1360-5.

LP-44物理化学性质

[ 分子式 ]:
C₂₇H₃₈ClN₃OS

[ 分子量 ]:
488.13

[ 精确质量 ]:
487.24200

[ PSA ]:
60.88000

[ LogP ]:
6.48050

[ 储存条件 ]:
-20°C，密闭，干燥

LP-44安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

LP-44文献

Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon.

PLoS ONE 6 , e24393, (2011)

Schistosoma infection is thought to lead to down-regulation of the host's immune response. This has been shown for adaptive immune responses, but the effect on innate immunity, that initiates and shap...

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