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GLP 1(1-37)(人类

GLP 1(1-37)(人类用途

Glucagon-like peptide 1 (1-37), human是有效的 GLP-1 受体激动剂。

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GLP 1(1-37)(人类名称

[ CAS 号 ]:
87805-34-3

[ 中文名 ]:
血糖素样肽-1

[ 英文名 ]:
GLP-1 (1-37) (human, bovine, guinea pig, mouse, rat) trifluoroacetate salt

[英文别名 ]:

Glucagon-like peptide 1 (1-37)
Glucagon-like peptide 1 (1-37) (human, rat)
Glucagon-like peptide 1 (1-37), human

GLP 1(1-37)(人类生物活性

[ 描述 ]:

Glucagon-like peptide 1 (1-37), human是有效的 GLP-1 受体激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胰高血糖素受体

多肽产品

研究领域 >> 代谢疾病

[ 靶点 ]

GLP-1 receptor[1]

[体外研究]

胰高血糖素样肽-1(GLP-1)通过胰高血糖素原的翻译后加工产生,并且充当各种稳态事件的调节剂。 GLP-1(1-37)比GLP-1(7-37)更稳定,在暴露于小鼠血清4小时后剩余94.7％的肽初始量。通过测量瞬时转染的人胚肾(HEK293)细胞中荧光素酶报告基因表达的表达,证实GLP-1(1-37)是GLP-1受体(GLP-1R)的高效激动剂[1]。。

[体内研究]

GLP-1(1-37)以剂量依赖性降低血糖波动。与对照组相比,GLP-1(1-37)或GLP-1(7-37)的给药在15分钟和30分钟时显着降低血糖水平[1]。

[细胞实验]

将HEK293细胞（5×104）接种在96孔板中，并用GLP-1R质粒和CRE-荧光素酶报道质粒瞬时共转染。转染48小时后，加入不同浓度的GLP-1（1-37）或GLP-1（7-37），将细胞培养5小时。使用荧光素酶测定法收获细胞用于荧光素酶测定[1]。

[动物实验]

小鼠[1]在施用（ip）GLP-1和葡萄糖之前，将正常KM小鼠禁食16小时。将含有或不含毒蜥外泌肽（9-39）（250nmol / kg）的GLP-1（1-37）（25nmol / kg）与葡萄糖（4g / kg）组合给予。具有或不具有毒蜥外泌肽（9-39）（250nmol / kg）的GLP-1（7-37）（25nmol / kg）也与葡萄糖（4g / kg）组合施用。对照组用盐水（NaCl，9g / l）和葡萄糖（4g / kg）处理。在葡萄糖和蛋白质给药后0,15,30和60分钟进行IPGTT，并如上所述测量血糖水平[1]。

[参考文献]

[1]. Zhao L, et al. Glucagon-like peptide-1(1-37) can enhance blood glucose homeostasis in mice. Regul Pept. 2012 Oct 10;178(1-3):1-5.

[相关活性小分子]

GLP 1(1-37)(人类物理化学性质

[ 分子式 ]:
C₁₈₆H₂₇₅N₅₁O₅₉

[ 分子量 ]:
4169.48

[ 储存条件 ]:
−20°C

GLP 1(1-37)(人类安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

GLP 1(1-37)(人类文献

GLP-1-related proteins attenuate the effects of mitochondrial membrane damage in pancreatic β cells.

Biochem. Biophys. Res. Commun. 447(1) , 133-8, (2014)

Glucagon-like peptide (GLP)-1 analog based therapies are used not only for their insulinotropic effects, but also for their pleiotropic effects that improve pancreatic β cell function. Liraglutide is ...

Glucagon-like peptide-1 and blood pressure in young and healthy adults from the general population.

Hypertension 65(2) , 306-12, (2015)

Hypertension and diabetes mellitus are highly correlated, but the underlying mechanisms are only partly understood. Therefore, the aim of our study was to investigate the relationships between plasma ...

The low level of glucagon-like peptide-1 (glp-1) is a risk factor of type 2 diabetes mellitus.

BMC Res. Notes 7 , 849, (2014)

Glucagon like peptide-1 (GLP-1), an incretin hormone, regulates glucose metabolism by inducing insulin secretion and suppressing glucagon secretion. The aim of the study is to assess the levels of fas...

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