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8-羟基-2-脱氧鸟苷

8-羟基-2-脱氧鸟苷用途

8-Hydroxy-2'-deoxyguanosine 是氧化应激和致癌反应的关键生物标志物。

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8-羟基-2-脱氧鸟苷名称

[ CAS 号 ]:
88847-89-6

[ 中文名 ]:
8-羟基-2-脱氧鸟苷

[ 英文名 ]:
8-hydroxy-2'-deoxyguanosine

[中文别名 ]:

[英文别名 ]:

2'-deoxy-7,8-dihydro-8-oxo-guanosine
MFCD00210311
2'-Deoxy-8-oxo-7,8-dihydroguanosine
7,8-Dihydro-8-oxo-2'-deoxyguanosine
2'-Deoxy-8-oxoguanosine
8-Oxo-7,8-dihydrodeoxyguanosine
2'-Deoxy-8-oxo-D-guanosine
8-Oxodeoxyguanosine
guanosine, 2'-deoxy-8-oxo-
2'-Deoxy-8-hydroxyguanosine

8-羟基-2-脱氧鸟苷生物活性

[ 描述 ]:

8-Hydroxy-2'-deoxyguanosine 是氧化应激和致癌反应的关键生物标志物。

[ 相关类别 ]:

研究领域 >> 癌症

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

8-羟基-2'-脱氧鸟苷(8-OHdG)是用于各种癌症和退行性疾病的风险评估的良好生物标志物。生物标志物8-羟基-2'-脱氧鸟苷(8-OHdG)或8-氧代G已经成为测量内源性氧化损伤对DNA的影响的关键标志物,并且是致癌作用的起始和促进因素。生物标志物已被用于估计人类接触致癌因子后的DNA损伤,如烟草烟雾,石棉纤维,重金属和多环芳烃[1]。

[参考文献]

[1]. Valavanidis A, et al. 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39.

[相关活性小分子]

8-羟基-2-脱氧鸟苷物理化学性质

[ 密度 ]:
2.3±0.1 g/cm3

[ 熔点 ]:
217-220ºC

[ 分子式 ]:
C₁₀H₁₃N₅O₅

[ 分子量 ]:
283.241

[ 精确质量 ]:
283.091675

[ PSA ]:
159.51000

[ LogP ]:
-1.32

[ 外观性状 ]:
白色固体

[ 折射率 ]:
1.955

[ 储存条件 ]:
2-8°C

8-羟基-2-脱氧鸟苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MF8782675

[ 海关编码 ]:
2934999090

8-羟基-2-脱氧鸟苷合成路线

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8-羟基-2-脱氧鸟苷下游产品

8-羟基-2-脱氧鸟苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

8-羟基-2-脱氧鸟苷文献

Complement-dependent NADPH oxidase enzyme activation in renal ischemia/reperfusion injury.

Free Radic. Biol. Med. 74 , 263-73, (2014)

NADPH oxidase plays a central role in mediating oxidative stress during heart, liver, and lung ischemia/reperfusion injury, but limited information is available about NADPH oxidase in renal ischemia/r...

Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells.

Oncotarget 6 , 36245-59, (2015)

Tyrosine kinase inhibitors (TKIs) including axitinib have been introduced in the treatment of renal cell carcinoma (RCC) because of their anti-angiogenic properties. However, no evidence are presently...

Effect of long-term human exposure to environmental heavy metals on the expression of detoxification and DNA repair genes.

Environ. Pollut. 181 , 226-32, (2013)

The present study was designed to evaluate the influence of long-term environmental human exposure to three heavy metals, lead (Pb), cadmium (Cd), and mercury (Hg), on the expression of detoxifying, x...

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