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2,4-二羟基苯甲酸

2,4-二羟基苯甲酸用途

2,4-Dihydroxybenzoic acid 是细胞培养中 tart cheeries 的降解产物。

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2,4-二羟基苯甲酸名称

[ CAS 号 ]:
89-86-1

[ 中文名 ]:
2,4-二羟基苯甲酸

[ 英文名 ]:
2,4-Dihydroxybenzoic acid

[中文别名 ]:

[英文别名 ]:

p-Hydroxysalicylic acid
b-resorcylic acid
2,4-dihydroxybenzoic_acid
4-Carboxyresorcinol
resorcylic acid
2,4-dihydroxy-benzoic acid
2,4-Dihydroxy benzoic acid
Benzoic acid, 2,4-dihydroxy-
2,4-Dihydroxybenzoic acid
2,4,6-TRIPHENYLPYRYLIUM TETRAFLUOROBORATE

2,4-二羟基苯甲酸生物活性

[ 描述 ]:

2,4-Dihydroxybenzoic acid 是细胞培养中 tart cheeries 的降解产物。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Seeram NP, et al. Degradation products of cyanidin glycosides from tart cherries and their bioactivities. J Agric Food Chem. 2001 Oct;49(10):4924-9.

[相关活性小分子]

2,4-二羟基苯甲酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
414.8±15.0 °C at 760 mmHg

[ 熔点 ]:
208-211 °C (dec.)(lit.)

[ 分子式 ]:
C₇H₆O₄

[ 分子量 ]:
154.120

[ 闪点 ]:
218.8±16.9 °C

[ 精确质量 ]:
154.026611

[ PSA ]:
77.76000

[ LogP ]:
1.60

[ 外观性状 ]:
灰白色至奶油色

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.671

[ 储存条件 ]:
室温

[ 水溶解性 ]:
8 g/L (20 ºC)

2,4-二羟基苯甲酸MSDS

2,4-二羟基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VH3708050

CHEMICAL NAME :: beta-Resorcylic acid

CAS REGISTRY NUMBER :: 89-86-1

BEILSTEIN REFERENCE NO. :: 1946213

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H6-O4

MOLECULAR WEIGHT :: 154.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 196,478,1976 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 642 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 38,209,1982

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2,4-二羟基苯甲酸安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
VH3708050

[ 海关编码 ]:
2942000000

2,4-二羟基苯甲酸合成路线

2,4-二羟基苯甲酸上下游产品

2,4-二羟基苯甲酸上游产品

2,4-二羟基苯甲酸下游产品

2,4-二羟基苯甲酸制备

1、间苯二酚羧基化法先将间苯二酚、碳酸氢钾和足够的水加入反应瓶中，在水浴加热4h，然后于直火上加热30min使其沸腾，在此期间内通入二氧化碳。反应完毕，用乙醚提取，以除去未反应的间苯二酚，所得水溶液用浓盐酸酸化，用水冷却到0℃，过滤、水洗，得粗品，经沸水重结晶即得成品。

2、3-羟基苯酚羧基化法在碳酸氢钾和碳酸氢钠混合物存在下，3-羟基苯酚与二氧化碳在110℃反应3h，得2,4-二羟基苯甲酸，产率99.7%。

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2,4-二羟基苯甲酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

2,4-二羟基苯甲酸文献

Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

J. Med. Chem. 54 , 591-602, (2011)

Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced...

Application of Electrochemiluminescence for the Evaluation of the Antioxidant Capacity of Some Phenolic Compounds Against Superoxide Anion Radicals.

Anal. Sci. 31 , 629-34, (2015)

This paper for the first time reports on novel and non-enzymatic method for studying the free radical-scavenging properties of phenolic compounds against superoxide anion radicals (O2·(-)) by using th...

3D-QSAR and molecular docking studies of benzaldehyde thiosemicarbazone, benzaldehyde, benzoic acid, and their derivatives as phenoloxidase inhibitors.

Bioorg. Med. Chem. 15 , 2006-15, (2007)

Phenoloxidase (PO), also known as tyrosinase, is a key enzyme in insect development, responsible for catalyzing the hydroxylation of tyrosine into o-diphenols and the oxidation of o-diphenols into o-q...

更多文献

2,4-二羟基苯甲酸

2,4-二羟基苯甲酸用途

2,4-二羟基苯甲酸名称

2,4-二羟基苯甲酸生物活性

2,4-二羟基苯甲酸物理化学性质

2,4-二羟基苯甲酸MSDS

详细MSDS(安全技术说明书)

2,4-二羟基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

2,4-二羟基苯甲酸安全信息

2,4-二羟基苯甲酸合成路线

详细合成路线

2,4-二羟基苯甲酸上下游产品

2,4-二羟基苯甲酸上游产品

2,4-二羟基苯甲酸下游产品

2,4-二羟基苯甲酸制备

2,4-二羟基苯甲酸海关

2,4-二羟基苯甲酸文献

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