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1,2,4-苯三酚

1,2,4-苯三酚用途

1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) 是咖啡豆烘焙的副产物,可增加大鼠胸腺淋巴细胞中 Ca2+ 浓度。

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1,2,4-苯三酚名称

[ CAS 号 ]:
533-73-3

[ 中文名 ]:
1,2,4-苯三酚

[ 英文名 ]:
1,2,4-Trihydroxybenzene

[中文别名 ]:

[英文别名 ]:

4-Hydroxycatechol
1,2,4-Trihydroxybenzene
1,2,4-Benzenetriol
1,3,4-Benzenetriol
1,2,3-Trihydroxybenzene
benzene-1,2,3-triol
EINECS 208-575-1
Hydroxyhydroquinone
Benzene-1,2,4-triol
Benzol-1,2,3-triol

1,2,4-苯三酚生物活性

[ 描述 ]:

1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) 是咖啡豆烘焙的副产物,可增加大鼠胸腺淋巴细胞中 Ca2+ 浓度。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 心血管疾病

[参考文献]

[1]. Risa Kamae, et al. Hydroxyhydroquinone, a by-product of coffee bean roasting, increases intracellular Ca²⁺ concentration in rat thymic lymphocytes. Food Chem Toxicol. 2017 Apr;102:39-45.

1,2,4-苯三酚物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
334.5±12.0 °C at 760 mmHg

[ 熔点 ]:
140 °C (subl.)(lit.)

[ 分子式 ]:
C₆H₆O₃

[ 分子量 ]:
126.110

[ 闪点 ]:
176.9±14.2 °C

[ 精确质量 ]:
126.031693

[ PSA ]:
60.69000

[ LogP ]:
0.06

[ 外观性状 ]:
暗蓝色粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.677

[ 储存条件 ]:
通风低温干燥,与库房食品原料分开存放

[ 水溶解性 ]:
freely soluble

1,2,4-苯三酚MSDS

详细MSDS(安全技术说明书)

1,2,4-苯三酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC4200000

CHEMICAL NAME :: 1,2,4-Benzenetriol

CAS REGISTRY NUMBER :: 533-73-3

BEILSTEIN REFERENCE NO. :: 2042863

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C6-H6-O3

MOLECULAR WEIGHT :: 126.12

WISWESSER LINE NOTATION :: QR BQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 122 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 umol/L

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 82,81,1989

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1,2,4-苯三酚安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S39-S36/37/39-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DC4200000

[ 海关编码 ]:
2907299090

1,2,4-苯三酚上下游产品

1,2,4-苯三酚上游产品

1,2,4-苯三酚下游产品

1,2,4-苯三酚制备

由对苯醌和乙酐制得1,2,4-苯三酚三乙酸酯，再与盐酸作用即得该品。1.1,2,4-苯三酚三乙酸酯的制备将干燥的对苯醌分次加入乙酐和浓硫酸的混合物中，反应温度为40-50℃，反应1-3h。向反应物加冷水，将析出的沉淀过滤、冷水洗涤，用醇重结晶，即得1,2,4-苯三酚三乙酸酯。熔点96.5-97℃。2.1,2,4-苯三酚的制备将5%盐酸与1,2,4-苯三酚三乙酸酯一起搅拌加热至90℃，水解20min，冷却。用碳酸钠中和，过滤。滤液用乙醚提取，将乙醚提取液加热蒸去乙醚，即得1,2,4-苯三酯。

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1,2,4-苯三酚海关

[ 海关编码 ]: 2907299090

[ 中文概述 ]:
2907299090 其他多元酚，酚醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

1,2,4-苯三酚文献

A convenient screening method to differentiate phenolic skin whitening tyrosinase inhibitors from leukoderma-inducing phenols.

J. Dermatol. Sci. 80 , 18-24, (2015)

Tyrosinase is able to oxidize a great number of phenols and catechols to form ortho-quinones. Ortho-quinones are highly reactive compounds that exert cytotoxicity through binding with thiol enzymes an...

Degradation of sulfonamide antibiotics by Microbacterium sp. strain BR1 - elucidating the downstream pathway.

New Biotechnology 32 , 710-5, (2015)

Microbacterium sp. strain BR1 is among the first bacterial isolates which were proven to degrade sulfonamide antibiotics. The degradation is initiated by an ipso-substitution, initiating the decay of ...

The TetR-type transcriptional repressor RolR from Corynebacterium glutamicum regulates resorcinol catabolism by binding to a unique operator, rolO.

Appl. Environ. Microbiol. 78(17) , 6009-16, (2012)

The rol (designated for resorcinol) gene cluster rolRHMD is involved in resorcinol catabolism in Corynebacterium glutamicum, and RolR is the TetR-type regulator. In this study, we investigated how Rol...

更多文献

1,2,4-苯三酚

1,2,4-苯三酚用途

1,2,4-苯三酚名称

1,2,4-苯三酚生物活性

1,2,4-苯三酚物理化学性质

1,2,4-苯三酚MSDS

详细MSDS(安全技术说明书)

1,2,4-苯三酚毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

1,2,4-苯三酚安全信息

1,2,4-苯三酚上下游产品

1,2,4-苯三酚上游产品

1,2,4-苯三酚下游产品

1,2,4-苯三酚制备

1,2,4-苯三酚海关

1,2,4-苯三酚文献

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