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2-羟基苄醇

2-羟基苄醇用途

Salicyl alcohol用作医药、香料、农药的中间体。

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2-羟基苄醇名称

[ CAS 号 ]:
90-01-7

[ 中文名 ]:
水杨醇

[ 英文名 ]:
salicyl alcohol

[中文别名 ]:

[英文别名 ]:

α-Hydroxy-o-cresol
2-Hydroxymethylphenol
salicyl alcohol
a,2-Dihydroxytoluene
MFCD00004617
Benzenemethanol, 2-hydroxy-
2-Hydroxybenzenemethanol
EINECS 201-960-5
2-(Hydroxymethyl)phenol
2-Hydroxybenzyl alcohol

2-羟基苄醇生物活性

[ 描述 ]:

Salicyl alcohol用作医药、香料、农药的中间体。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[相关活性小分子]

2-羟基苄醇物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
238.6±7.0 °C at 760 mmHg

[ 熔点 ]:
83-85 °C(lit.)

[ 分子式 ]:
C₇H₈O₂

[ 分子量 ]:
124.137

[ 闪点 ]:
115.2±12.8 °C

[ 精确质量 ]:
124.052429

[ PSA ]:
40.46000

[ LogP ]:
0.30

[ 外观性状 ]:
淡棕色结晶粉末

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.596

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents.

[ 水溶解性 ]:
67 g/L (22 ºC)

2-羟基苄醇MSDS

详细MSDS(安全技术说明书)

2-羟基苄醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DO6430000

CHEMICAL NAME :: Benzyl alcohol, o-hydroxy-

CAS REGISTRY NUMBER :: 90-01-7

BEILSTEIN REFERENCE NO. :: 1907195

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C7-H8-O2

MOLECULAR WEIGHT :: 124.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 400 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 38,209,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80312 No. of Facilities: 141 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 3095 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80312 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 108 (estimated) No. of Female Employees: 72 (estimated)

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2-羟基苄醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DO6430000

[ 海关编码 ]:
29072900

2-羟基苄醇合成路线

详细合成路线

2-羟基苄醇上下游产品

2-羟基苄醇上游产品

2-羟基苄醇下游产品

2-羟基苄醇制备

1.有苯酚和甲醛溶液的混合物中加入乙酸锌，调pH为5-6，缓缓加热回流1小时，真空蒸馏除去水分和过量的苯酚，温度不超过100℃。釜中残留物用四氯化碳搅匀后静置，析出的水杨醇再用四氯化碳结晶一次得成品。

2.制法：

于高压反应釜中加入2mol/L的氯化亚铁水溶液1.5mL，氧化铂0.5g，水杨醛(2)73.2g(0.6mol),95%的乙醇300mL。用氮气置换空气，再用氢气置换氮气。于0.3MPa压力下，室温搅拌至不再吸收氢气为止，约需1～2h。放出残压，打开反应釜。加入1mol/L的氢氧化钠溶液1～2mL，过滤回收催化剂，用20mL(95%)的乙醇洗涤。合并滤液和洗涤液，旋转浓缩，剩余物用150mL苯重结晶，得产物^①(1)67.9，收率92%。注：①采用此方法可以制备如下各种苄醇（表I-5-7）

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2-羟基苄醇海关

[ 海关编码 ]: 2907299090

[ 中文概述 ]:
2907299090 其他多元酚，酚醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

2-羟基苄醇文献

Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.

J. Med. Chem. 48 , 7234-42, (2005)

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspas...

Functional characterization of two acyltransferases from Populus trichocarpa capable of synthesizing benzyl benzoate and salicyl benzoate, potential intermediates in salicinoid phenolic glycoside biosynthesis.

Phytochemistry 113 , 149-59, (2015)

Salicinoids are phenolic glycosides (PGs) characteristic of the Salicaceae and are known defenses against insect herbivory. Common examples are salicin, salicortin, tremuloidin, and tremulacin, which ...

Salicyl alcohol oxidase of the chemical defense secretion of two chrysomelid leaf beetles. Molecular and functional characterization of two new members of the glucose-methanol-choline oxidoreductase gene family.

J. Biol. Chem. 283(28) , 19219-28, (2008)

Salicyl alcohol oxidase is an extracellular enzyme that occurs in glandular reservoirs of chrysomelid leaf beetle larvae and catalyzes the formation of salicylaldehyde, a volatile deterrent used by th...

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2-羟基苄醇

2-羟基苄醇用途

2-羟基苄醇名称

2-羟基苄醇生物活性

2-羟基苄醇物理化学性质

2-羟基苄醇MSDS

详细MSDS(安全技术说明书)

2-羟基苄醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

2-羟基苄醇安全信息

2-羟基苄醇合成路线

详细合成路线

2-羟基苄醇上下游产品

2-羟基苄醇上游产品

2-羟基苄醇下游产品

2-羟基苄醇制备

2-羟基苄醇海关

2-羟基苄醇文献

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