微晶纤维素

纤维素可以用作赋形剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。

[ 描述 ]:

[ 相关类别 ]:

[ 靶点 ]

[参考文献]

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
237.6±35.0 °C at 760 mmHg

[ 熔点 ]:
260-270ºC

[ 分子式 ]:
C₆H₁₀O₅

[ 分子量 ]:
160.255

[ 闪点 ]:
91.8±14.5 °C

[ 精确质量 ]:
160.125198

[ LogP ]:
4.75

[ 外观性状 ]:
粉红色粉末

[ 蒸汽压 ]:
0.1±0.2 mmHg at 25°C

[ 折射率 ]:
1.529

[ 储存条件 ]:
库房低温通风干燥

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
insoluble | insoluble

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

FJ5691460

CHEMICAL NAME :

Cellulose

CAS REGISTRY NUMBER :

9004-34-6

LAST UPDATED :

199712

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: (Suppl),243,1992

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>5800 mg/m3/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: (Suppl),243,1992

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>31600 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 50A,83,1972

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

>2 gm/kg

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: (Suppl),243,1992 *** REVIEWS *** ACGIH TLV-TWA 10 mg/m3, total dust DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993 OEL-BELGIUM:TWA 10 mg/m3 JAN 1993 OEL-FRANCE:TWA 10 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993 OEL-RUSSIA:TWA 2 mg/m3;STEL 4 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 6 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 10 mg/m3;STEL 20 mg/m3 (total dust) JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3 (resp. dust) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CELLULOSE, respirable fraction-air:10H TWA 5 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CELLULOSE, total dust-air:10H TWA 10 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
37

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
FJ5950200

[ 海关编码 ]:
3912900000

详细合成路线

微晶纤维素上游产品

微晶纤维素下游产品

（1）纤维素是世界上蕴藏量最丰富的天然高分子化合物，生产原料来源于木材、棉花、棉短绒、麦草、稻草、芦苇、麻、桑皮、楮皮和甘蔗渣等。我国由于森林资源不足，纤维素的原料有70%来源于非木材资源。我国针叶材、阔叶材的纤维素平均含量约43-45%；草类茎秆的纤维素平均含量在40%左右。纤维素的工业制法是用亚硫酸盐溶液或碱溶液蒸煮植物原料，主要是除去木素，分别称为亚硫酸盐法和碱法。得到的物料称为亚硫酸盐浆和碱法浆。然后经过漂白进一步除去残留木素，所得漂白浆可用于造纸。再进一步除去半纤维素，就可用作纤维素衍生物的原料。用纤维植物原料与无机酸捣成浆状，制成α-纤维素，再经处理使纤维素作部分解聚，然后再除去非结晶部分并提纯而得。将选好的工业木浆板疏解，然后送入已加1%～10%的盐酸(用量为5%～10%)的反应釜进行升温水解，温度为90～100℃，水解时间0.5～2h，反应结束后经冷却送人中和槽，用液碱调至中性，过滤后滤饼在80～100℃下干燥，最后经粉碎得产品。由木浆或棉花浆制成的纤维素。经漂白处理和机械分散后精制而成。

（2）将选好的工业木浆板疏解，然后送入已加1%～10%的盐酸(用量为5%～10%)的反应釜进行升温水解，温度为90～100℃，水解时间0.5～2h，反应结束后经冷却送人中和槽，用液碱调至中性，过滤后滤饼在80～100℃下干燥，最后经粉碎得产品。

（3）用纤维植物原料与无机酸捣成浆状,制成α - 纤维素,再经处理使纤维素作部分解聚,然后再除去非结晶部分并提纯而得。

[ 海关编码 ]: 3912900000

Shape control of cellulose nanocrystals via compositional acid hydrolysis.

J. Biomed. Nanotechnol. 9(7) , 1293-8, (2013)

The current medical technology has constantly demanded novel and advanced materials exhibiting the unique physicochemical properties but, at the same time, possessing the intrinsic biocompatibility. N...

Lignin valorization: improving lignin processing in the biorefinery.

Science 344(6185) , 1246843, (2014)

Research and development activities directed toward commercial production of cellulosic ethanol have created the opportunity to dramatically increase the transformation of lignin to value-added produc...

Aspergillus niger β-glucosidase has a cellulase-like tadpole molecular shape: insights into glycoside hydrolase family 3 (GH3) β-glucosidase structure and function.

J. Biol. Chem. 288(46) , 32991-3005, (2013)

Aspergillus niger is known to secrete large amounts of β-glucosidases, which have a variety of biotechnological and industrial applications. Here, we purified an A. niger β-glucosidase (AnBgl1) and co...

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：微晶纤维素粉

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公司名：南通润丰石油化工有限公司

区域：南通市崇川区

价格：
￥需询单/1kg ￥需询单/1ton

联系人：曹经理

产品详情：微晶纤维素

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥118.0/100g ￥288.0/500g ￥458.0/1kg ￥98.0/100g

联系人：刘佳

产品详情：纤维素粉

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥332.9/1kg ￥167.9/250g ￥387.9/1kg ￥187.9/250g

联系人：阿拉丁

产品详情：纤维素粉

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公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥182.0/250g ￥363.0/1kg ￥72.0/50g ￥184.0/250g

联系人：夏言

产品详情：[Perfemiker]纤维素粉,粒径：100μm

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