乙酰基异丁香酚

乙酰基异丁香酚用途

Isoeugenol acetate 是一种肉豆蔻,丁香和肉桂的精油成分,对某些代谢酶如乙酰胆碱酯酶 (AChE) 酶 (IC50=77 nM; Ki=16 nM),α-糖苷酶 (IC50=19.25 nM; Ki=21 nM) 和 α-淀粉酶 (IC50=411.5 nM) 具有良好的抑制作用。 Isoeugenol acetate 用于医疗和化妆品工业,具有抗氧化,抗癌,抗菌和抗炎特性。

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乙酰基异丁香酚名称

[ CAS 号 ]:
93-29-8

[ 中文名 ]:
乙酸异丁香酚酯

[ 英文名 ]:
Acetylisoeugenol

[中文别名 ]:

[英文别名 ]:

2-Methoxy-4-[(1E)-1-propenyl]phenyl acetate
EINECS 202-236-1
2-Methoxy-4-[(1E)-prop-1-en-1-yl]phenyl acetate
Phenol, 2-methoxy-4-[(1E)-1-propen-1-yl]-, acetate
MFCD00026984
2-Methoxy-4-[(1E)-1-propen-1-yl]phenylacetat
2-Methoxy-4-[(1E)-1-propen-1-yl]phenyl acetate
Phenol, 2-methoxy-4-(1-propenyl)-, acetate, (E)-
Acétate de 2-méthoxy-4-[(1E)-1-propèn-1-yl]phényle
1-acetoxy-2-methoxy-4-(1-propenyl)benzene

乙酰基异丁香酚生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 炎症/免疫

信号通路 >> 神经信号通路 >> 疼痛

[ 靶点 ]

IC50: 77 nM (AChE), 19.25 nM (α-glycosidase), 411.5 nM (α-amylase)[1] Ki: 16 nM (AChE), 21 nM (α-glycosidase)[1]

[参考文献]

[1]. Fevzi Topal.Anticholinergic and antidiabetic effects of isoeugenol from clove (Eugenia caryophylata) oil. International Journal of Food Properties, 22:1,583-592.

[2]. Hyldgaard M, et al. Isoeugenol has a non-disruptive detergent-like mechanism of action. Front Microbiol. 2015 Jul 28;6:754.

乙酰基异丁香酚物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
283.0±20.0 °C at 760 mmHg

[ 熔点 ]:
79-81 °C(lit.)

[ 分子式 ]:
C₁₂H₁₄O₃

[ 分子量 ]:
206.238

[ 闪点 ]:
113.9±16.4 °C

[ 精确质量 ]:
206.094299

[ PSA ]:
35.53000

[ LogP ]:
2.54

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.539

[ 储存条件 ]:
库房通风低温干燥

乙酰基异丁香酚MSDS

详细MSDS(安全技术说明书)

乙酰基异丁香酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL7940000

CHEMICAL NAME :: Phenol, 2-methoxy-4-propenyl-, acetate

CAS REGISTRY NUMBER :: 93-29-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C12-H14-O3

MOLECULAR WEIGHT :: 206.26

WISWESSER LINE NOTATION :: 2U1R CO1 DOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,819,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,819,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83234 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 394 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83234 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

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乙酰基异丁香酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
SL7940000

乙酰基异丁香酚制备

将异丁香酚(iso-Euegnol)与乙酐在带空气冷凝器的反应罐中沸腾3h，然后蒸去乙酸及残余的乙酐，即得固体状物，再用乙醇重结晶精制而得。

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乙酰基异丁香酚文献

Parallel dual secondary column-dual detection: a further way of enhancing the informative potential of two-dimensional comprehensive gas chromatography.

J. Chromatogr. A. 1360 , 264-74, (2014)

Comprehensive two-dimensional gas chromatography (GC×GC) coupled with Mass Spectrometry (MS) is one of today's most powerful analytical platforms for detailed analysis of medium-to-high complexity sam...

Isoeugenol is an important contact allergen: can it be safely replaced with isoeugenyl acetate?

Contact Dermatitis 41(5) , 272-5, (1999)

The prevalence of contact allergy to the fragrance mix in individuals with eczema is up to 10%. Within the mix, isoeugenol (CAS 97-54-1) is an important individual allergen. Until May 1998, the IFRA (...

Contact allergy to isoeugenol and its derivatives: problems with allergen substitution.

Contact Dermatitis 51(5-6) , 288-91, (2004)

A total of 2261 (808 male, 1453 female) consecutive patients attending contact dermatitis clinics were patch tested to isoeugenol and its derivatives listed in the EU Inventory of Fragrance Ingredient...

更多文献

乙酰基异丁香酚

乙酰基异丁香酚用途

乙酰基异丁香酚名称

乙酰基异丁香酚生物活性

乙酰基异丁香酚物理化学性质

乙酰基异丁香酚MSDS

详细MSDS(安全技术说明书)

乙酰基异丁香酚毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

乙酰基异丁香酚安全信息

乙酰基异丁香酚制备

乙酰基异丁香酚文献

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