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马来酸溴苯那敏

马来酸溴苯那敏用途

Brompheniramine马来酸盐是组胺H1受体拮抗剂。

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马来酸溴苯那敏名称

[ CAS 号 ]:
980-71-2

[ 中文名 ]:
马来酸溴苯那敏

[ 英文名 ]:
Brompheniramine Maleate

[英文别名 ]:

D-Brompheniramine
dl-Bromopheniramine Maleate
Brompheniramine Maleate
(±)-Brompheniramine maleate
Brompheniramine d
Ilvin Maleate
(RS)-brompheniramine
MFCD00057367
EINECS 213-562-9
PARABROMODYLAMINE MALEATE

马来酸溴苯那敏生物活性

[ 描述 ]:

Brompheniramine马来酸盐是组胺H1受体拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 炎症/免疫

[参考文献]

[1]. http://en.wikipedia.org/wiki/Brompheniramine

[2]. Simons, F.E., E.M. Frith, and K.J. Simons, The pharmacokinetics and antihistaminic effects of brompheniramine. J Allergy Clin Immunol, 1982. 70(6): p. 458-64.

[相关活性小分子]

马来酸溴苯那敏物理化学性质

[ 沸点 ]:
403ºC at 760 mmHg

[ 熔点 ]:
134-135ºC

[ 分子式 ]:
C₂₀H₂₃BrN₂O₄

[ 分子量 ]:
435.312

[ 精确质量 ]:
434.084106

[ PSA ]:
90.73000

[ LogP ]:
3.63950

[ 外观性状 ]:
晶体粉末

[ 储存条件 ]:
库房通风低温干燥,与食品原料类分开存放

[ 水溶解性 ]:
水溶性：可溶

马来酸溴苯那敏MSDS

详细MSDS(安全技术说明书)

马来酸溴苯那敏毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US4025000

CAS REGISTRY NUMBER :: 980-71-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H19-Br-N2.C4-H4-O4

MOLECULAR WEIGHT :: 435.36

WISWESSER LINE NOTATION :: T6NJ BYR DE&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 318 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,19,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 76 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,19,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84807 No. of Facilities: 967 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 3990 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84807 No. of Facilities: 314 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 6708 (estimated) No. of Female Employees: 3572 (estimated)

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马来酸溴苯那敏安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
UN 3249

[ WGK德国 ]:
3

[ RTECS号 ]:
US4025000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2934999090

马来酸溴苯那敏海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

马来酸溴苯那敏文献

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J. Anal. Toxicol. 38(6) , 360-7, (2014)

The discovery of two cocaine-N-oxide (CNO) diastereomers, syn- and anti-CNO, is reported for the first time. Prior to this study, only one structural form of CNO was known to exist and has not been an...

H1-antihistamines and oxidative burst of professional phagocytes.

Neuro Endocrinol. Lett. 30 Suppl 1 , 133-6, (2009)

We analysed and compared the effect of five H1-antihistamines on stimulated oxidative burst at extra- and intracellular level of isolated and stimulated human polymorphonuclear leukocytes.Oxidative bu...

Pheniramines and oxidative burst of blood phagocytes during ischaemia/reperfusion.

Inflamm. Res. 58 Suppl 1 , 66-7, (2009)

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