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盐酸屈他维林

盐酸屈他维林用途

屈他维林(盐酸)是一种4型环核苷酸磷酸二酯酶(PDE4)抑制剂和一种L型电压依赖性钙通道(L-VDCC)阻滞剂,可阻止3',5'-环磷酸腺苷的降解。屈他维林(盐酸)在体内具有解痉功效,无抗胆碱能作用。

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盐酸屈他维林名称

[ CAS 号 ]:
985-12-6

[ 中文名 ]:
盐酸屈他维林

[ 英文名 ]:
Drotaverine hydrochloride

[中文别名 ]:

盐酸屈维林

[英文别名 ]:

DROTAVERINE HCL
DROTAVERINE HYDROCHLORIDE
Drotaverinium chloride
Isodihydroperparine hydrochloride
MFCD01754602
Drotaverin hydrochloride
Tetraspasmin-Lefa
No-Spa hydrochloride

盐酸屈他维林生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)

[参考文献]

[1]. Patai Z, Guttman A, Mikus EG. Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine. Pharmacology. 2018;101(3-4):163-169.

盐酸屈他维林物理化学性质

[ 密度 ]:
1.097 g/cm3

[ 沸点 ]:
564ºC at 760 mmHg

[ 熔点 ]:
208-212ºC

[ 分子式 ]:
C₂₄H₃₂ClNO₄

[ 分子量 ]:
433.968

[ 闪点 ]:
240.7ºC

[ 精确质量 ]:
433.201996

[ PSA ]:
48.95000

[ LogP ]:
6.05600

[ 外观性状 ]:
灰白-黄色结晶固体

[ 储存条件 ]:
-20°C Freezer

盐酸屈他维林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX5014000

CHEMICAL NAME :: Isoquinoline, 1,2,3,4-tetrahydro-6,7-diethoxy-1-((3,4-diethoxypheny l)methylene)-, hydrochloride

CAS REGISTRY NUMBER :: 985-12-6

LAST UPDATED :: 199606

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C24-H31-N-O4.Cl-H

MOLECULAR WEIGHT :: 434.02

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366

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盐酸屈他维林安全信息

[ 海关编码 ]:
2933990090

盐酸屈他维林海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%