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beta-胸苷

beta-胸苷用途

【用途一】
主要用于抗艾滋病药物（如齐多呋啶、石达呋啶）的制备。
【用途二】
用作医药中间体，用于合成抗病毒和抗HIV药
【用途三】
主要用于抗艾滋病药物（如齐多呋啶、石达呋啶）的制备

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beta-胸苷名称

[ CAS 号 ]:
50-89-5

[ 中文名 ]:
胸苷

[ 英文名 ]:
Thymidine

[中文别名 ]:

[英文别名 ]:

Thymidine
2'-deoxy-5-methyluridine
T6NVMVJ E1 A- ET5OTJ B1Q CQ &&Ribo Form
SS-THYMIDINE
Thyminedeoxyriboside
2'-dT
1-(2-Deoxy-b-D-ribofuranosyl)-5-methyluracil
Zidovudine Related Compound D
EINECS 200-070-4
deoxyribosylthymine

beta-胸苷生物活性

[ 描述 ]:

Thymidine是嘧啶脱氧核苷。

[ 相关类别 ]:

天然产物 >> 生物碱

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16(9):7980-93.

[相关活性小分子]

beta-胸苷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
510.1±60.0 °C at 760 mmHg

[ 熔点 ]:
187-189ºC

[ 分子式 ]:
C₁₀H₁₄N₂O₅

[ 分子量 ]:
242.229

[ 闪点 ]:
262.3±32.9 °C

[ 精确质量 ]:
242.090271

[ PSA ]:
104.55000

[ LogP ]:
-0.90

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.674

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

beta-胸苷MSDS

beta-胸苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XP2071000

CHEMICAL NAME :: Thymidine

CAS REGISTRY NUMBER :: 50-89-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: C10-H14-N2-O5

MOLECULAR WEIGHT :: 242.26

WISWESSER LINE NOTATION :: T6NVMVJ E1 A- ET5OTJ B1Q CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2512 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 400 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 20 gm/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 800 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 150 mmol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7245 No. of Facilities: 213 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 578 (estimated) No. of Female Employees: 141 (estimated)

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beta-胸苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XP2071000

beta-胸苷合成路线

beta-胸苷上下游产品

beta-胸苷上游产品

beta-胸苷下游产品

beta-胸苷文献

DNase II-dependent DNA digestion is required for DNA sensing by TLR9.

Nat. Commun. 6 , 5853, (2015)

DNase II digests DNA in endolysosomes. In the absence of DNase II, undigested DNA activates cytoplasmic DNA-sensing pathways. Little is known, however, about the role of DNase II in endolysosomal DNA ...

Oncogene-mediated regulation of p53 ISGylation and functions.

Oncotarget 5(14) , 5808-18, (2014)

Oncogene-mediated cellular transformation is a multistep process involving activation of growth-promoting pathways as well as inactivation of tumor suppressors. We recently found that ISGylation of th...

Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells.

Nat. Commun. 6 , 6240, (2015)

Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusiv...

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