罗红霉素
罗红霉素结构式
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常用名 | 罗红霉素 | 英文名 | Roxithromycin |
|---|---|---|---|---|
| CAS号 | 80214-83-1 | 分子量 | 837.047 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 864.7±75.0 °C at 760 mmHg | |
| 分子式 | C41H76N2O15 | 熔点 | 115- 120ºC | |
| MSDS | 中文版 美版 | 闪点 | 476.7±37.1 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.
BMC Biol. 13 , 52, (2015) Malaria invasion of red blood cells involves multiple parasite-specific targets that are easily accessible to inhibitory compounds, making it an attractive target for antimalarial development. However, no current antimalarial agents act against host cell inva... |
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A comparison of in vitro ADME properties and pharmacokinetics of azithromycin and selected 15-membered ring macrolides in rodents.
Eur. J. Drug Metab. Pharmacokinet. 39(4) , 263-76, (2014) The purpose of this study was to evaluate the impact of structural modifications on the 15-membered macrolactone ring and/or substituents on the in vitro ADME properties and in vivo pharmacokinetic (PK) profile for selected derivatives in rodents in compariso... |
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Stability of dicyclohexylamine and fumagillin in honey.
Food Chem. 179 , 152-8, (2015) Fumagillin is extensively used to control nosema disease in apiculture. In the commercial formulation, fumagillin is present as a salt in an equimolar quantity with dicyclohexylamine (DCH). In this study DCH was observed to be significantly more resistant to ... |
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Simple and accurate quantitative analysis of 20 anti-tuberculosis drugs in human plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry.
J. Pharm. Biomed. Anal. 102 , 9-16, (2014) A simple and accurate liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method for the quantitation of 20 anti-tuberculosis (anti-TB) drugs in human plasma, was developed as a tool for therapeutic drug monitoring. Two protein precipitation methods w... |
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Maternal intravenous administration of azithromycin results in significant fetal uptake in a sheep model of second trimester pregnancy.
Antimicrob. Agents Chemother. 58(11) , 6581-91, (2014) Treatment of intrauterine infection is likely key to preventing a significant proportion of preterm deliveries before 32 weeks of gestation. Azithromycin (AZ) may be an effective antimicrobial in pregnancy; however, few gestation age-approriate data are avail... |
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Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.
Antimicrob. Agents Chemother. 58(6) , 3168-76, (2014) Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS c... |
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Rapid and selective extraction of multiple macrolide antibiotics in foodstuff samples based on magnetic molecularly imprinted polymers.
Talanta 137 , 1-10, (2015) Magnetic molecularly imprinted polymers (MMIPs) were prepared based on surface molecular imprinting using erythromycin (ERY) as template molecule and Fe3O4 nanoparticles as support substrate. The MMIPs possessed high adsorption capacity of 94.1 mg/g for ERY a... |
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Single-step multiresidue determination of ten multiclass veterinary drugs in pork, milk, and eggs using liquid chromatography with tandem mass spectrometry.
J. Sep. Sci. 38 , 2772-80, (2015) A multiclass, multiresidue determination method is reported for the detection of ten veterinary drugs, including scopolamine, metoclopramide, acriflavine, berberine, tripelennamine, diphenhydramine, acrinol, triamcinolone, loperamide, and roxithromycin in por... |
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Passive sampling: A cost-effective method for understanding antibiotic fate, behaviour and impact.
Environ. Int. 85 , 284-91, (2015) The occurrence of antibiotics in the environment has raised much concern in recent years. Understanding their release, fate and behaviour in the environment is vital to assess potential risks. In this study, a novel passive water sampler - diffusion gradients... |
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Ultra-high performance liquid chromatography-electrospray tandem mass spectrometry for the analysis of antibiotic residues in environmental waters.
Environ. Sci. Pollut. Res. Int. 22 , 16857-67, (2015) An optimized solid-phase extraction (SPE) and ultra-high performance liquid chromatography-electrospray tandem mass spectrometry (UPLC-MS/MS) method was developed for the effective analysis of 35 antibiotics including sulfonamides (SAs), quinolones (QLs), tet... |