西奈芬净
西奈芬净结构式
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常用名 | 西奈芬净 | 英文名 | Sinefungin |
|---|---|---|---|---|
| CAS号 | 58944-73-3 | 分子量 | 381.39 | |
| 密度 | 1.9±0.1 g/cm3 | 沸点 | 783.2±70.0 °C at 760 mmHg | |
| 分子式 | C15H23N7O5 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 427.5±35.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats.
Br. J. Pharmacol. 172(3) , 857-68, (2015) AT1 receptor blockers (ARBs) represent an approach for treating metabolic syndrome due to their potency in reducing hypertension, body weight and onset of type 2 diabetes. The mechanism underlying ARB-induced weight loss is still unclear.Leptin resistance tes... |
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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.
Mol. Cancer Ther. 8 , 1579-1588, (2009) DNA methylation, histone modifications, and nucleosomal occupancy collaborate to cause silencing of tumor-related genes in cancer. The development of drugs that target these processes is therefore important for cancer therapy. Inhibitors of DNA methylation an... |
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Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.
FEBS J. 277(9) , 2096-108, (2010) The protein arginine methyltransferase (PRMT) family of enzymes catalyzes the transfer of methyl groups from S-adenosylmethionine to the guanidino nitrogen atom of peptidylarginine to form monomethylarginine or dimethylarginine. We created several less polar ... |
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Conformational transitions as determinants of specificity for the DNA methyltransferase EcoRI.
J. Biol. Chem. 281(37) , 26821-31, (2006) Changes in DNA bending and base flipping in a previously characterized specificity-enhanced M.EcoRI DNA adenine methyltransferase mutant suggest a close relationship between precatalytic conformational transitions and specificity (Allan, B. W., Garcia, R., Ma... |
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The Caulobacter crescentus DNA-(adenine-N6)-methyltransferase CcrM methylates DNA in a distributive manner.
Nucleic Acids Res. 40 , 1708-16, (2012) The specificity and processivity of DNA methyltransferases have important implications regarding their biological functions. We have investigated the sequence specificity of CcrM and show here that the enzyme has a high specificity for GANTC sites, with only ... |
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Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA.
Proc. Natl. Acad. Sci. U. S. A. 111(17) , 6275-80, (2014) Aminoglycosides are potent, broad spectrum, ribosome-targeting antibacterials whose clinical efficacy is seriously threatened by multiple resistance mechanisms. Here, we report the structural basis for 30S recognition by the novel plasmid-mediated aminoglycos... |
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Characterization of a mimivirus RNA cap guanine-N2 methyltransferase.
RNA 15 , 666-74, (2009) A 2,2,7-trimethylguanosine (TMG) cap is a signature feature of eukaryal snRNAs, telomerase RNAs, and trans-spliced nematode mRNAs. TMG and 2,7-dimethylguanosine (DMG) caps are also present on mRNAs of two species of alphaviruses (positive strand RNA viruses o... |