人参皂苷Rh1
人参皂苷Rh1结构式
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常用名 | 人参皂苷Rh1 | 英文名 | Ginsenoside Rh1 |
|---|---|---|---|---|
| CAS号 | 63223-86-9 | 分子量 | 638.872 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 755.1±60.0 °C at 760 mmHg | |
| 分子式 | C36H62O9 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 410.5±32.9 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea.
J. Nat. Prod. 70(7) , 1203-6, (2007) Three 20(S)-protopanaxatriol-type saponins, ginsenoside-Rg1 (1), notoginsenoside-R1 (2), and ginsenoside-Re (3), were transformed by the fungus Absidia coerulea (AS 3.3389). Compound 1 was converted into five metabolites, ginsenoside-Rh4 (4), 3beta,2beta,25-t... |
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[Studies on chemical constituents from rhizomes of Panax notoginseng].
Zhong Yao Cai 30(11) , 1388-91, (2007) To study the chemical constituents from rhizomes of Panax notoginseng.The constituents were isolated and purified by various chromatogragraphic methods, all compounds were identified on the basis of special analysis and physicochemical characters.Eight compou... |
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Antibiotics attenuate anti-scratching behavioral effect of ginsenoside Re in mice.
J. Ethnopharmacol. 142(1) , 105-112, (2012) The root of Panax ginseng CA Meyer (ginseng) has been used for diabetes, cancer, stress and allergic diseases in the traditional Chinese medicine.To understand the role of intestinal microflora in the pharmacological effect of ginsenoside Re, which is a main ... |
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Enzymatic preparation of ginsenosides Rg2, Rh1, and F1 from protopanaxatriol-type ginseng saponin mixture.
Planta Med. 69(3) , 285-6, (2003) During investigations on the hydrolysis of a protopanaxatriol-type saponin mixture by various glycoside hydrolases, it was found that two minor saponins, ginsenosides Rg 2 and Rh 1, were formed in high yields by crude beta-galactosidase from Aspergillus oryza... |
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Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol.
J. Pharmacol. Sci. 109(4) , 504-10, (2009) Ginsenoside Rg1 has been reported to improve cognitive function in many memory-impaired animal models. However, little is known about the bioactivity of its metabolites in the central nervous system in vivo. In the present study, we employed the step through ... |
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Determination of 20(S)-ginsenoside Rh1 and its aglycone 20(S)-protopanaxatriol in rat plasma by sensitive LC-APCI-MS method and its application to pharmacokinetic study.
Eur. J. Mass Spectrom. (Chichester, Eng.) 15(1) , 57-65, (2009) Liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry (LC-APCI-MS) method has been developed for the measurement of the concentrations of 20(S)-ginsenoside Rh1 and its aglycone 20(S)-protopanaxatriol in rat plasma with panaxatriol a... |
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Cloning and heterologous expression of UDP-glycosyltransferase genes from Bacillus subtilis and its application in the glycosylation of ginsenoside Rh1.
Lett. Appl. Microbiol. 60(1) , 72-8, (2015) Bacillus subtilis CCTCC AB 2012913 can transform ginsenoside Rh1 to 3-O-β-D-glucopyranosyl-6-O-β-D-glucopyranosyl-20(S)-protopanaxatriol. Based on its genome sequence, strain B. subtilis 168 contains three UDP-glycosyltransferase genes. Here, we cloned the th... |
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[Pharmacokinetics of ginsenosides Rg1 and its metabolites in rats].
Yao Xue Xue Bao 45(5) , 636-40, (2010) To study the pharmacokinetics of ginsenosides Rg1 and its metabolites after iv and oral administration in Wistar rats, the LC-MS/MS method was selected to determine ginsenosides Rg1 and its metabolites in plasma and their pharmacokinetic parameters were calcu... |
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Oral administration of ginsenoside Rh1 inhibits the development of atopic dermatitis-like skin lesions induced by oxazolone in hairless mice.
Int. Immunopharmacol. 11(4) , 511-8, (2011) In the present study, we examined the inhibitive effect of ginsenoside Rh1 on oxazolone-induced atopic dermatitis-like skin lesions in hairless mice. Oral administration of ginsenoside Rh1 improved clinical symptoms, and it was confirmed by histophathological... |
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Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities.
Int. Arch. Allergy Immunol. 133(2) , 113-20, (2004) Ginseng (the root of Panax ginseng C.A. Meyer, Araliaceae) has been reported to possess various biological activities, including anti-inflammatory and antitumor actions. In this study, we investigated the antiallergic activity of ginsenosides isolated from gi... |