L-亮氨酸-4-硝基苯胺
L-亮氨酸-4-硝基苯胺结构式
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常用名 | L-亮氨酸-4-硝基苯胺 | 英文名 | N-(4-Nitrophenyl)-L-leucinamide |
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| CAS号 | 4178-93-2 | 分子量 | 251.282 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 454.5±30.0 °C at 760 mmHg | |
| 分子式 | C12H17N3O3 | 熔点 | 88-90ºC | |
| MSDS | 中文版 美版 | 闪点 | 228.7±24.6 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.
PLoS ONE 10(2) , e0115859, (2015) Malaria is a parasitic disease that remains a global health burden. The ability of the parasite to rapidly develop resistance to therapeutics drives an urgent need for the delivery of new drugs. The Medicines for Malaria Venture have compounds known for their... |
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Beta-phenyl cysteine: a leucine aminopeptidase inhibitor.
Pharmacol. Res. Commun. 16(6) , 533-8, (1984) Beta-phenyl cysteine: a leucine aminopeptidase inhibitor. The kinetic parameters of the inhibition of the leucine aminopeptidase by beta-phenyl cysteine are reported in this communication. |
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Exploration of structural and physicochemical requirements and search of virtual hits for aminopeptidase N inhibitors.
Mol. Divers. 17(1) , 123-37, (2013) Aminopeptidase N (APN) inhibitors have been reported to be effective in treating of life threatening diseases including cancer. Validated ligand- and structure-based pharmacophore mapping approaches were combined with Bayesian modeling and recursive partition... |
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Covalent immobilisation of protease and laccase substrates onto siloxanes.
Chemosphere 80(8) , 922-8, (2010) Immobilisation of enzyme substrates is a powerful tool in the detection of enzymes in the chemosphere and the environment. A siloxane based strategy for the covalent immobilisation of oxidoreductase and protease substrates was developed involving activation o... |
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The leucyl aminopeptidase from Helicobacter pylori is an allosteric enzyme.
Microbiology 151(Pt 6) , 2017-23, (2005) This study describes the cloning, genetic analysis and biochemical characterization of a leucyl aminopeptidase (LAP) from Helicobacter pylori. A gene encoding LAP was cloned from H. pylori and the expressed 55 kDa protein displayed homology to aminopeptidases... |
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Aminopeptidase M from human liver. I. Solubilization, purification, and some properties of the enzyme.
J. Biochem. 106(5) , 818-25, (1989) Aminopeptidase M [EC 3.4.11.2] was purified 772-fold to homogeneity from the microsomal fraction of human liver, with a yield of 18.9%, by a combination of solubilization with 0.5% Triton X-100 and then 1 M urea and chromatography on columns of DEAE-cellulose... |
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Overexpression, purification, and characterization of the recombinant leucine aminopeptidase II of Bacillus stearothermophilus.
Curr. Microbiol. 47(1) , 40-5, (2003) For expression of Bacillus stearothermophilus NCIB 8924 leucine aminopeptidase II (LAP II) in Escherichia coli regulated by a T5 promoter, the gene was amplified by polymerase chain reaction and cloned into expression vector pQE-32 to generate pQE-LAPII. The ... |
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Relationship of chloroquine-induced redistribution of a neutral aminopeptidase to hemoglobin accumulation in malaria parasites.
Arch. Biochem. Biophys. 410(2) , 296-306, (2003) To study the relationship between neutral aminopeptidase activity and hemoglobin accumulation in malaria parasites, we treated mice infected with Plasmodium berghei NYU-2 with chloroquine intraperitoneally in doses ranging from 0.3 to 3 micromol per 25 g mous... |
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Photoinactivation of peptide transport in Saccharomyces cerevisiae.
Biochemistry 21(23) , 5967-71, (1982) Oligopeptides and dipeptides are transported into Saccharomyces cerevisiae by a carrier-mediated system. In the dark, leucyl-p-nitroanilide (Leu-p-NA) and leucyl-leucyl-4-azido-2-nitrophenylalanine [Leu-Leu-Phe-(4N3,2NO2)] are competitive inhibitors of peptid... |
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Enzymatic tracer damage during the gonadotropin releasing hormone radioimmunoassay: analytical and immunological assessment.
Life Sci. 37(12) , 1155-65, (1985) Hypothalamic supernatants from 60 day female rats were fractionated from Sephadex G-200 columns. The radioimmunoassay (RIA) for gonadotropin releasing hormone (GnRH) detected an apparently cross-reacting high molecular weight substance. The substance caused a... |