Omuralide结构式
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常用名 | Omuralide | 英文名 | Omuralide |
|---|---|---|---|---|
| CAS号 | 154226-60-5 | 分子量 | 213.230 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 462.9±45.0 °C at 760 mmHg | |
| 分子式 | C10H15NO4 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 233.7±28.7 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Proteasome inhibitor differentially regulates expression of the major immediate early genes of human cytomegalovirus in human central nervous system-derived cell lines.
Virus Res. 142(1-2) , 68-77, (2009) Proteasome inhibitor, which inhibits NF-kappaB activation, has been reported to activate c-Jun N-terminal kinase (JNK)-c-Jun pathway. In this study, we investigated the effects of proteasome inhibitor on the human cytomegalovirus (HCMV) major immediate early ... |
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Turnover of StAR protein: roles for the proteasome and mitochondrial proteases.
Mol. Cell. Endocrinol. 265-266 , 51-8, (2007) Steroidogenic acute regulatory protein (StAR) is a mitochondrial protein essential for massive synthesis of steroid hormones in the adrenal and the gonads. Our studies suggest that once synthesized on free polyribosomes, StAR preprotein either associates with... |
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Targeting of a chlamydial protease impedes intracellular bacterial growth.
PLoS Pathog. 7(9) , e1002283, (2011) Chlamydiae are obligate intracellular bacteria that propagate in a cytosolic vacuole. Recent work has shown that growth of Chlamydia induces the fragmentation of the Golgi apparatus (GA) into ministacks, which facilitates the acquisition of host lipids into t... |
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Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala.
PLoS ONE 6(9) , e24349, (2011) Protein degradation through the ubiquitin-proteasome system [UPS] plays a critical role in some forms of synaptic plasticity. However, its role in memory formation in the amygdala, a site critical for the formation of fear memories, currently remains unknown.... |
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Proteasome inhibition triggers activity-dependent increase in the size of the recycling vesicle pool in cultured hippocampal neurons.
J. Neurosci. 26(44) , 11333-41, (2006) The ubiquitin proteasome system, generally known for its function in protein degradation, also appears to play an important role in regulating membrane trafficking. A role for the proteasome in regulating presynaptic release and vesicle trafficking has been p... |
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Ubiquitin-proteasome pathway function is required for lens cell proliferation and differentiation.
Invest. Ophthalmol. Vis. Sci. 47(6) , 2569-75, (2006) The ubiquitin proteasome pathway is involved in the regulation of many cellular processes, such as cell cycle control, signal transduction, transcription, and removal of obsolete proteins. The objective of this work was to investigate roles for this proteolyt... |
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Opposite effects of proteasome inhibitors in the adrenergic induction of arylalkylamine N-acetyltransferase in rat pinealocytes.
Chronobiol. Int. 23(1-2) , 361-7, (2006) In the rat pineal gland, the steady-state level of arylalkylamine N-acetyltransferase (AANAT) protein is controlled by transcriptional and translational mechanisms as well as by proteasome-mediated degradation. Studies with proteasome inhibitors, MG132 and cl... |
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Enantioselective total syntheses of (-)-clasto-lactacystin beta-lactone and 7-epi-(-)-clasto-lactacystin beta-lactone.
Org. Biomol. Chem. 4(2) , 193-5, (2006) An alkylidene carbene 1,5-CH insertion has been used as a key step in an efficient enantioselective total synthesis of (-)-clasto-lactacystin beta-lactone, and its C7-epimer. An additional noteworthy feature of the synthesis is the use of a novel oxidative de... |
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Utility of the ammonia-free Birch reduction of electron-deficient pyrroles: total synthesis of the 20s proteasome inhibitor, clasto-lactacystin beta-lactone.
Chemistry 11(14) , 4227-38, (2005) A new synthesis of the 20S proteasome inhibitor clasto-lactacystin beta-lactone is described. Our route to this important natural product involves the partial reduction of an electron deficient pyrrole as a key step. By judicious choice of enolate counterion,... |
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Proteasomal degradation regulates expression of porphobilinogen deaminase (PBGD) mutants of acute intermittent porphyria.
Biochim. Biophys. Acta 1762(9) , 819-27, (2006) Acute intermittent porphyria (AIP) is a neuropathic disease caused by a dominant inherited deficiency in porphobilinogen deaminase (PBGD). We investigated the expression and the degradation of the human PBGD-mutations G748A, G748C and 887insA following transf... |