美曲勃龙
美曲勃龙结构式
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常用名 | 美曲勃龙 | 英文名 | Methyltrienolone |
|---|---|---|---|---|
| CAS号 | 965-93-5 | 分子量 | 284.393 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 485.9±45.0 °C at 760 mmHg | |
| 分子式 | C19H24O2 | 熔点 | 206-209 °C | |
| MSDS | 中文版 美版 | 闪点 | 206.3±21.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Bisphenol A affects androgen receptor function via multiple mechanisms
Chem. Biol. Interact. 203(3) , 556-64, (2013) • BPA antagonizes AR function by competitive inhibition of androgen binding. • Prevents functional foci formation in the nucleus. • Reduce the AR presence in the nucleus. • BPAF have similar activation function in ERα and inhibition in AR as BPA. • BPS is a w... |
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Hydrazinobenzoylcurcumin inhibits androgen receptor activity and growth of castration-resistant prostate cancer in mice.
Oncotarget 6(8) , 6136-50, (2015) There is a critical need for therapeutic agents that can target the amino-terminal domain (NTD) of androgen receptor (AR) for the treatment of castration-resistant prostate cancer (CRPC). Calmodulin (CaM) binds to the AR NTD and regulates AR activity. We disc... |
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The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.
Oncotarget 5(6) , 1666-82, (2014) Prostate cancer (PCa) is among the leading causes of cancer-related death in men. Androgen receptor (AR) signaling plays a seminal role in prostate development and homeostasis, and dysregulation of this pathway is intimately linked to prostate cancer pathogen... |
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Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells.
Oncotarget 6 , 13088-104, (2015) Prostate cancer progression to castration refractory disease is associated with anomalous transcriptional activity of the androgen receptor (AR) in an androgen-depleted milieu. To identify novel gene products whose downregulation transactivates AR in prostate... |
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Interlaboratory comparison of in vitro bioassays for screening of endocrine active chemicals in recycled water.
Water Res. 83 , 303-9, (2015) In vitro bioassays have shown promise as water quality monitoring tools. In this study, four commercially available in vitro bioassays (GeneBLAzer(®) androgen receptor (AR), estrogen receptor-alpha (ER), glucocorticoid receptor (GR) and progesterone receptor ... |
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Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy.
Oncotarget 6(8) , 6105-22, (2015) Androgen deprivation therapy induces apoptosis or cell cycle arrest in prostate cancer (PCa) cells. Here we set out to analyze whether MCL1, a known mediator of chemotherapy resistance regulates the cellular response to androgen withdrawal. Analysis of MCL1 p... |
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CH5137291, an androgen receptor nuclear translocation-inhibiting compound, inhibits the growth of castration-resistant prostate cancer cells.
Int. J. Oncol. 46(4) , 1560-72, (2015) Resistance of prostate cancer to castration is currently an unavoidable problem. The major mechanisms underlying such resistance are androgen receptor (AR) overexpression, androgen-independent activation of AR, and AR mutation. To address this problem, we dev... |
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GATA3 in the urinary bladder: suppression of neoplastic transformation and down-regulation by androgens.
Am. J. Cancer Res. 4(5) , 461-73, (2014) Recent evidence suggests the involvement of sex hormone receptors in bladder cancer initiation, while precise functions of androgens and estrogens in the carcinogenesis step remain poorly understood. We recently found down-regulation of GATA3, a zinc-finger t... |
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Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices.
Sci. Rep. 5 , 17187, (2015) Precision-cut slices of in vivo tumours permit interrogation in vitro of heterogeneous cells from solid tumours together with their native microenvironment. They offer a low throughput but high content in vitro experimental platform. Using mouse models as sur... |
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Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN.
Oncotarget 6 , 15137-49, (2015) Androgen Receptor (AR) is the male hormone receptor and a nuclear transcription factor which plays a central role in the growth of normal and malignant prostate gland. Our earlier studies defined a mechanistic model for male hormone dependent regulation of AR... |