PIT-1
PIT-1结构式
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常用名 | PIT-1 | 英文名 | PIT-1 |
|---|---|---|---|---|
| CAS号 | 53501-41-0 | 分子量 | 351.765 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C14H10ClN3O4S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
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Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.
Proc. Natl. Acad. Sci. U. S. A. 107(46) , 20126-31, (2010) The PI3-kinase (PI3K) pathway regulates many cellular processes, especially cell metabolism, cell survival, and apoptosis. Phosphatidylinositol-3,4,5-trisphosphate (PIP3), the product of PI3K activity and a key signaling molecule, acts by recruiting pleckstri... |
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Inhibition of cell migration by PITENINs: the role of ARF6.
Oncogene 31(39) , 4317-32, (2012) We have reported previously the development of small-molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including activation of Akt, and show anti-tumor potential. Here we show t... |
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