RAD51抑制剂B02
RAD51抑制剂B02结构式
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常用名 | RAD51抑制剂B02 | 英文名 | B02 |
|---|---|---|---|---|
| CAS号 | 1290541-46-6 | 分子量 | 339.39000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C22H17N3O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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A novel role for non-ubiquitinated FANCD2 in response to hydroxyurea-induced DNA damage.
Oncogene 35 , 22-34, (2016) Fanconi anemia (FA) is a genetic disease of bone marrow failure, cancer susceptibility, and sensitivity to DNA crosslinking agents. FANCD2, the central protein of the FA pathway, is monoubiquitinated upon DNA damage, such as crosslinkers and replication block... |
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Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function.
PLoS Genet. 9 , e1003910, (2013) In checkpoint-deficient cells, DNA double-strand breaks (DSBs) are produced during replication by the structure-specific endonuclease MUS81. The mechanism underlying MUS81-dependent cleavage, and the effect on chromosome integrity and viability of checkpoint ... |
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