扎那米韦
扎那米韦结构式
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常用名 | 扎那米韦 | 英文名 | Zanamivir |
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| CAS号 | 139110-80-8 | 分子量 | 332.310 | |
| 密度 | 1.8±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C12H20N4O7 | 熔点 | 256ºC (dec.) | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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Cochrane researchers continue to face challenges over access to data on flu drugs.
BMJ 346 , f3190, (2013)
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Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.
J. Med. Chem. 56(3) , 671-84, (2013) In order to exploit the 430-cavity in the active sites of neuraminidases, 22 zanamivir analogs with C-1 and C-4 modification were synthesized, and their inhibitory activities against both group-1 (H5N1, H1N1) and group-2 neuraminidases (H3N2) were determined.... |
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Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity.
Science 340(6128) , 71-5, (2013) Influenza antiviral agents play important roles in modulating disease severity and in controlling pandemics while vaccines are prepared, but the development of resistance to agents like the commonly used neuraminidase inhibitor oseltamivir may limit their fut... |
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Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors.
Nat. Commun. 4 , 1491, (2013) Development of novel influenza neuraminidase inhibitors is critical for preparedness against influenza outbreaks. Knowledge of the neuraminidase enzymatic mechanism and transition-state analogue, 2-deoxy-2,3-didehydro-N-acetylneuraminic acid, contributed to t... |
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Influenza viruses with B/Yamagata- and B/Victoria-like neuraminidases are differentially affected by mutations that alter antiviral susceptibility.
J. Antimicrob. Chemother. 70 , 2004-12, (2015) The burden of disease due to influenza B is often underestimated. Clinical studies have shown that oseltamivir, a widely used neuraminidase inhibitor (NAI) antiviral drug, may have reduced effectiveness against influenza B viruses. Therefore, it is important ... |
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A beneficiary role for neuraminidase in influenza virus penetration through the respiratory mucus.
PLoS ONE 9(10) , e110026, (2014) Swine influenza virus (SIV) has a strong tropism for pig respiratory mucosa, which consists of a mucus layer, epithelium, basement membrane and lamina propria. Sialic acids present on the epithelial surface have long been considered to be determinants of infl... |
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Competitive fitness of influenza B viruses with neuraminidase inhibitor-resistant substitutions in a coinfection model of the human airway epithelium.
J. Virol. 89(8) , 4575-87, (2015) Influenza A and B viruses are human pathogens that are regarded to cause almost equally significant disease burdens. Neuraminidase (NA) inhibitors (NAIs) are the only class of drugs available to treat influenza A and B virus infections, so the development of ... |
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Strain-specific antiviral activity of iminosugars against human influenza A viruses.
J. Antimicrob. Chemother. 70(1) , 136-52, (2014) Drugs that target host cell processes can be employed to complement drugs that specifically target viruses, and iminosugar compounds that inhibit host α-glucosidases have been reported to show antiviral activity against multiple viruses. Here the effect and m... |
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Synergistic effect of nitazoxanide with neuraminidase inhibitors against influenza A viruses in vitro.
Antimicrob. Agents Chemother. 59(2) , 1061-9, (2015) The emergence of drug-resistant influenza A virus (IAV) strains represents a serious threat to global human health and underscores the need for novel approaches to anti-influenza chemotherapy. Combination therapy with drugs affecting different IAV targets rep... |
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Neuraminidase-producing oral mitis group streptococci potentially contribute to influenza viral infection and reduction in antiviral efficacy of zanamivir.
Cell. Mol. Life Sci. 72(2) , 357-66, (2015) Influenza is a serious respiratory disease among immunocompromised individuals, such as the elderly, and its prevention is an urgent social issue. Influenza viruses rely on neuraminidase (NA) activity to release progeny viruses from infected cells and spreadi... |