柯诺辛B

更新时间：2025-08-23 21:15:54

柯诺辛B结构式	常用名	柯诺辛B	英文名	Corynoxine B
	CAS号	17391-18-3	分子量	384.469
	密度	1.2±0.1 g/cm3	沸点	560.8±50.0 °C at 760 mmHg
	分子式	C₂₂H₂₈N₂O₄	熔点	N/A
	MSDS	N/A	闪点	293.0±30.1 °C

柯诺辛B用途

柯诺辛B(Corynoxine B)是吲哚生物碱天然化合物，一个beclin-1-dependent自噬诱导剂。

中文名	柯诺辛B
英文名	rhynchophylline
英文别名	更多

描述	柯诺辛B(Corynoxine B)是吲哚生物碱天然化合物,一个beclin-1-dependent自噬诱导剂。
相关类别	信号通路 >> 自噬 >> 自噬天然产物 >> 生物碱研究领域 >> 癌症
参考文献	[1]. Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10(1):144-54. [2]. Sakakibara I, et al. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis. Phytomedicine. 1998 Apr;5(2):83-6.

描述

柯诺辛B(Corynoxine B)是吲哚生物碱天然化合物,一个beclin-1-dependent自噬诱导剂。

相关类别

信号通路 >> 自噬 >> 自噬

天然产物 >> 生物碱

研究领域 >> 癌症

参考文献

[1]. Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10(1):144-54.

[2]. Sakakibara I, et al. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis. Phytomedicine. 1998 Apr;5(2):83-6.

密度	1.2±0.1 g/cm3
沸点	560.8±50.0 °C at 760 mmHg
分子式	C₂₂H₂₈N₂O₄
分子量	384.469
闪点	293.0±30.1 °C
精确质量	384.204895
PSA	67.87000
LogP	3.31
InChIKey	DAXYUDFNWXHGBE-XYEDMTIPSA-N
SMILES	CCC1CN2CCC3(C(=O)Nc4ccccc43)C2CC1C(=COC)C(=O)OC
蒸汽压	0.0±1.5 mmHg at 25°C
折射率	1.596
储存条件	-20°C

去氢钩藤碱

630-94-4

~96%

柯诺辛B

17391-18-3

文献：Wanner, Martin J.; Ingemann, Steen; Van Maarseveen, Jan H.; Hiemstra, Henk European Journal of Organic Chemistry, 2013 , # 6 p. 1100 - 1106

柯诺辛B上游产品 1
CAS号630-94-4 去氢钩藤碱
柯诺辛B下游产品 0

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来源：ChEMBL
靶标：Aorta
External Id：CHEMBL1671303

实验名称：HepG2 viability counterscreen (readout 2: ATP content) against the NCATS DSHEA and TC...
来源：NCGC
靶标：N/A
External Id：DSHEA-v1-HepG2-viability-CTG-ATP

实验名称：Vasodilatory activity in Sprague-Dawley rat thoracic aorta smooth muscle assessed as ...
来源：ChEMBL
靶标：Aorta
External Id：CHEMBL1671304

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来源：ChEMBL
靶标：Kappa-type opioid receptor
External Id：CHEMBL4808362

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来源：NCGC
External Id：DSHEA-v1-PXR-antagonist-CTF

实验名称：Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK2...
来源：ChEMBL
靶标：Mu-type opioid receptor
External Id：CHEMBL4808363

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来源：NCGC
External Id：DSHEA-v1-PXR-antagonist-ONEGlo

实验名称：Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in C...
来源：ChEMBL
靶标：Delta-type opioid receptor
External Id：CHEMBL4808360

实验名称：Displacement of [3H]U69593 from human recombinant kappa opioid receptor expressed in ...
来源：ChEMBL
靶标：Kappa-type opioid receptor
External Id：CHEMBL4808361

实验名称：Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK2...
来源：ChEMBL
靶标：Mu-type opioid receptor
External Id：CHEMBL4808364

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