沃利替尼

更新时间：2025-08-25 15:54:31

沃利替尼结构式	常用名	沃利替尼	英文名	Savolitinib
	CAS号	1313725-88-0	分子量	345.361
	密度	1.6±0.1 g/cm3	沸点	N/A
	分子式	C₁₇H₁₅N₉	熔点	N/A
	MSDS	N/A	闪点	N/A

沃利替尼用途

Savolitinib(Volitinib; AZD-6094; Volitinib)是c-Met激酶口服型抑制剂，IC50值为5nM。

中文名	沃利替尼
英文名	(S)-1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine
英文别名	更多

描述	Savolitinib (AZD6094) 是高效,选择性的 c-Met 抑制剂,IC50 值为5 nM。
相关类别	信号通路 >> 蛋白酪氨酸激酶 >> c-Met的/HGFR 研究领域 >> 癌症
参考文献	[1]. Jia H, et al. Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (volitinib) as a highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitor in clinical development for treatment of cancer. J Med Chem. 2014 Sep 25;57(18):7577-89. [2]. Schuller A, et al. The MET inhibitor AZD6094 (Savolitinib, HMPL-504) induces regression in papillary renal cell carcinoma patient derived xenograft models. Clin Cancer Res. 2015 Mar 16. pii: clincanres.2685.2014. [3]. Noh CK, et al. Simultaneous quantification of volitinib and gefitinib in rat plasma by HPLC-MS/MS for application to a pharmacokinetic study in rats. J Sep Sci. 2017 Jul 27.

描述

Savolitinib (AZD6094) 是高效,选择性的 c-Met 抑制剂,IC50 值为5 nM。

相关类别

信号通路 >> 蛋白酪氨酸激酶 >> c-Met的/HGFR

研究领域 >> 癌症

参考文献

[1]. Jia H, et al. Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (volitinib) as a highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitor in clinical development for treatment of cancer. J Med Chem. 2014 Sep 25;57(18):7577-89.

[2]. Schuller A, et al. The MET inhibitor AZD6094 (Savolitinib, HMPL-504) induces regression in papillary renal cell carcinoma patient derived xenograft models. Clin Cancer Res. 2015 Mar 16. pii: clincanres.2685.2014.

[3]. Noh CK, et al. Simultaneous quantification of volitinib and gefitinib in rat plasma by HPLC-MS/MS for application to a pharmacokinetic study in rats. J Sep Sci. 2017 Jul 27.

密度	1.6±0.1 g/cm3
分子式	C₁₇H₁₅N₉
分子量	345.361
精确质量	345.145050
PSA	91.61000
LogP	0.54
InChIKey	XYDNMOZJKOGZLS-NSHDSACASA-N
SMILES	CC(c1ccc2nccn2c1)n1nnc2ncc(-c3cnn(C)c3)nc21
外观性状	粉末
折射率	1.833
储存条件	-20℃

危害码 (欧洲)	N

实验名称：Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhib...
来源：ChEMBL
靶标：Aurora kinase A
External Id：CHEMBL3991630

实验名称：Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhib...
来源：ChEMBL
靶标：Serine/threonine-protein kinase ATR
External Id：CHEMBL3991629

实验名称：Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhib...
来源：ChEMBL
靶标：Breakpoint cluster region protein
External Id：CHEMBL3991632

实验名称：Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhib...
来源：ChEMBL
靶标：Aurora kinase B
External Id：CHEMBL3991631

实验名称：Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhib...
来源：ChEMBL
靶标：Serine/threonine-protein kinase A-Raf
External Id：CHEMBL3991628

实验名称：Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhib...
来源：ChEMBL
靶标：Adenine phosphoribosyltransferase
External Id：CHEMBL3991627

实验名称：Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhib...
来源：ChEMBL
靶标：Tyrosine-protein kinase BTK
External Id：CHEMBL3991638

实验名称：Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhib...
来源：ChEMBL
靶标：Serine/threonine-protein kinase B-raf
External Id：CHEMBL3991637

实验名称：Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhib...
来源：ChEMBL
靶标：Bone morphogenetic protein receptor type-1A
External Id：CHEMBL3991634

实验名称：Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhib...
来源：ChEMBL
靶标：BMP-2-inducible protein kinase
External Id：CHEMBL3991633

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