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氟喹酮

氟喹酮用途

Afloqualone是一种GABA_A受体β亚型激动剂。

氟喹酮名称

[ CAS 号 ]:
56287-74-2

[ 中文名 ]:
氟喹酮

[ 英文名 ]:
Afloqualone

[英文别名 ]:

氟喹酮生物活性

[ 描述 ]:

Afloqualone是一种GABA_A受体β亚型激动剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体
信号通路 >> 神经信号通路 >> GABA受体
研究领域 >> 神经疾病

[参考文献]

[1]. Yamamura M, et al. Effects of afloqualone, a new centrally acting muscle relaxant, on DRL response and CER in rats (author's transl). Nihon Yakurigaku Zasshi. 1981 Oct;78(4):381-92.


[相关活性小分子]

(+)-荷包牡丹碱； 右旋荷包牡丹碱； 毕枯枯林； 山乌龟碱 | 木防己苦毒素 | 羧甲氧基胺半盐酸盐 | 利鲁唑 | 巴氯芬 | 巴米沙尼 | (R)-巴氯芬(mM/ml) | 艾替伏辛 | 依托咪酯 | 银杏内酯 A | 3'-[5-(1-羟基-1-甲基乙基)-1H-苯并咪唑-1-基]-[1,1'-联苯]-2-甲腈 | 5alpha-孕甾-3alpha-醇-20-酮 | 4-苄氧基苯基异硫氰酸酯 | L-655708 | 1-(2-((3R,5R,8R,9R,10S,13S,14S,17S)-3-羟基-3,13-二甲基十六氢-1H-环戊二烯并[a]菲-17-基)-2-氧代乙基)-1H-吡唑-4-甲腈

氟喹酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
492.5±55.0 °C at 760 mmHg

[ 熔点 ]:
195-196ºC

[ 分子式 ]:
C16H14FN3O

[ 分子量 ]:
283.300

[ 闪点 ]:
251.7±31.5 °C

[ 精确质量 ]:
283.112091

[ PSA ]:
60.91000

[ LogP ]:
1.28

[ 外观性状 ]:
白色至浅黄色结晶或结晶性粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.642

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

氟喹酮MSDS

详细MSDS(安全技术说明书)

氟喹酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA2350000
CHEMICAL NAME :
4(3H)-Quinazolinone, 6-amino-2-fluoromethyl-3-(o-tolyl)-
CAS REGISTRY NUMBER :
56287-74-2
BEILSTEIN REFERENCE NO. :
0819769
LAST UPDATED :
199612
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C16-H14-F-N3-O
MOLECULAR WEIGHT :
283.33
WISWESSER LINE NOTATION :
T66 BVN ENJ CR B1& D1F IZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
249 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 17,991,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
385 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 17,991,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
823 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 17,991,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
397 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 17,991,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
272 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 17,991,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
591 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 17,991,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6 gm/kg/30D-C
TOXIC EFFECTS :
Blood - normocytic anemia Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 17,991,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9100 mg/kg/26W-C
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 17,991,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1500 mg/kg/30D-C
TOXIC EFFECTS :
Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 17,991,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
5460 mg/kg/26W-C
TOXIC EFFECTS :
Liver - other changes Blood - other changes Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 17,991,1983

氟喹酮合成路线

详细合成路线

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公司名：上海化源生化科技有限公司

区域：上海市普陀区

价格：

联系人：化源网

产品详情：氟喹酮

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Afloqualone

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥492.9/100mg ￥999.9/250mg ￥1599.9/500mg ￥需询单/1g

联系人：阿拉丁

产品详情：氟喹酮

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相关化合物

【氟喹酮】化源网提供氟喹酮CAS号56287-74-2，氟喹酮MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询氟喹酮上化源网，专业又轻松。>>电脑版：氟喹酮

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