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L-655708

L-655708用途

L-655708是有效的, 选择性GABA A 受体激动剂 (Ki = 0.45 nM).

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L-655708名称

[ CAS 号 ]:
130477-52-0

[ 中文名 ]:
L-655708

[ 英文名 ]:
L-655,708

[英文别名 ]:

l-655,708
L-655708

L-655708生物活性

[ 描述 ]:

L-655708是有效的, 选择性GABA A 受体激动剂 (Ki = 0.45 nM).

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

信号通路 >> 神经信号通路 >> GABA受体

研究领域 >> 神经疾病

[参考文献]

[1]. Saab BJ, et al. Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptorinverse agonist L-655708. Anesthesiology. 2010 Nov;113(5):1061-1071.

[相关活性小分子]

L-655708物理化学性质

[ 密度 ]:
1.42g/cm3

[ 沸点 ]:
584.4ºC at 760mmHg

[ 分子式 ]:
C₁₈H₁₉N₃O₄

[ 分子量 ]:
341.36100

[ 闪点 ]:
307.2ºC

[ 精确质量 ]:
341.13800

[ PSA ]:
73.66000

[ LogP ]:
2.28620

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
1.21E-13mmHg at 25°C

[ 折射率 ]:
1.675

[ 储存条件 ]:
2-8℃

L-655708MSDS

详细MSDS(安全技术说明书)

L-655708安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

L-655708文献

Rat and human hippocampal alpha5 subunit-containing gamma-aminobutyric AcidA receptors have alpha5 beta3 gamma2 pharmacological characteristics.

Mol. Pharmacol. 54 , 928-933, (1998)

The gamma-aminobutyric acid (GABA)A receptor is a hetero-oligomer consisting of five subunits, the combination of which confers unique pharmacological properties to the receptor. To understand the phy...

Autoradiographic localization of alpha5 subunit-containing GABAA receptors in rat brain.

Brain Res. 822 , 265-270

Multiple subtypes of GABAA receptors are expressed in the rat central nervous system (CNS). To determine the distribution and proportion of alpha5 subunit containing receptors, quantitative autoradiog...

Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors.

Neuropsychopharmacology 40 , 2499-509, (2015)

Selective serotonin reuptake inhibitors (SSRIs) are the primary pharmacological treatment for depression, but SSRIs are effective in only half of the patients and typically take several weeks to relie...

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