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(R)-巴氯芬(mM/ml)

(R)-巴氯芬(mM/ml)用途

(R)-Baclofen(STX209)是选择性GABAB受体激动剂。

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(R)-巴氯芬(mM/ml)名称

[ CAS 号 ]:
69308-37-8

[ 中文名 ]:
(R)-巴氯芬

[ 英文名 ]:
(R)-Baclofen

[中文别名 ]:

(R)-4-氨基-3-(4-氯苯基)丁酸

[英文别名 ]:

(R)-(-)-Baclofen
(βR)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid
Z1YR DG&1VQ &&(R)-(-)- Form
(-)-Baclofen
(R)-(-)-4-Amino-3-(4-chlorophenyl)butanoic acid
(3R)-4-Amino-3-(4-chlorophenyl)butyric acid
(3R)-4-Amino-3-(4-chlorophenyl)butanoic acid
(R)-Baclofen
(R)-4-Amino-3-(4-chlorophenyl)butanoic acid
Arbaclofen

(R)-巴氯芬(mM/ml)生物活性

[ 描述 ]:

(R)-Baclofen(STX209)是选择性GABAB受体激动剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

信号通路 >> 神经信号通路 >> GABA受体

研究领域 >> 神经疾病

[参考文献]

[1]. Falch E, Hedegaard A, Nielsen L et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47(3):898-903.

[2]. Hong YG, Henry JL. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur J Pharmacol. 1991 Apr 24;196(3):267-75.

[3]. Orsnes G, Crone C, Krarup C et al. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol. 2000 Aug;111(8):1372-9.

[4]. Colombo G, Addolorato G, Agabio R et al. Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox Res. 2004;6(5):403-14.

[5]. Stetkarova I, Yablon SA, Kofler M, Stokic DS. Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review. Neurorehabil Neural Repair. 2010 Sep;24(7):609-19.

[相关活性小分子]

(R)-巴氯芬(mM/ml)物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
364.3±32.0 °C at 760 mmHg

[ 熔点 ]:
171-174°C

[ 分子式 ]:
C₁₀H₁₂ClNO₂

[ 分子量 ]:
213.661

[ 闪点 ]:
174.1±25.1 °C

[ 精确质量 ]:
213.055649

[ PSA ]:
63.32000

[ LogP ]:
1.56

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.577

[ 储存条件 ]:
Store at RT

(R)-巴氯芬(mM/ml)

(R)-巴氯芬(mM/ml)用途

(R)-巴氯芬(mM/ml)名称

(R)-巴氯芬(mM/ml)生物活性

(R)-巴氯芬(mM/ml)物理化学性质

(R)-巴氯芬(mM/ml)MSDS

详细MSDS(安全技术说明书)

(R)-巴氯芬(mM/ml)合成路线

详细合成路线

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