<生产厂家价格>

R-(+)-盐酸巴氯芬

R-(+)-盐酸巴氯芬用途

(R)-Baclofen(STX-209)盐酸盐是GABA衍生物。

R-(+)-盐酸巴氯芬名称

[ CAS 号 ]:
63701-55-3

[ 中文名 ]:
R(+)-巴氯芬盐酸盐

[ 英文名 ]:
(R)-Baclofen (hydrochloride)

[中文别名 ]:

R-(+)-巴氯芬盐酸盐

[英文别名 ]:

Arbaclofen HCl
d-Baclofen hydrochloride
MFCD00078579
Arbaclofen hydrochloride
(R)-Baclofen (hydrochloride)

R-(+)-盐酸巴氯芬生物活性

[ 描述 ]:

(R)-Baclofen(STX-209)盐酸盐是GABA衍生物。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

信号通路 >> 神经信号通路 >> GABA受体

研究领域 >> 神经疾病

[参考文献]

[1]. Mezler M, et al. Cloning and functional expression of GABA(B) receptors from Drosophila. Eur J Neurosci. 2001 Feb;13(3):477-86.

[2]. Dzitoyeva S, et al. Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5485-90. Epub 2003 Apr 11.

[相关活性小分子]

R-(+)-盐酸巴氯芬物理化学性质

[ 沸点 ]:
364.3ºC at 760 mmHg

[ 分子式 ]:
C₁₀H₁₃Cl₂NO₂

[ 分子量 ]:
250.12200

[ 闪点 ]:
174.1ºC

[ 精确质量 ]:
249.03200

[ PSA ]:
63.32000

[ LogP ]:
3.35930

[ 储存条件 ]:
-20°C，密闭，干燥

R-(+)-盐酸巴氯芬MSDS

R-(+)-盐酸巴氯芬毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MW5084350

CHEMICAL NAME :: Hydrocinnamic acid, beta-(aminomethyl)-p-chloro-, hydrochloride, (R)-

CAS REGISTRY NUMBER :: 63701-55-3

LAST UPDATED :: 198503

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-Cl-N-O2.Cl-H

MOLECULAR WEIGHT :: 250.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 523 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 32,187,1980

R-(+)-盐酸巴氯芬安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ RTECS号 ]:
MW5084350

R-(+)-盐酸巴氯芬合成路线

R-(+)-盐酸巴氯芬上下游产品

R-(+)-盐酸巴氯芬上游产品

R-(+)-盐酸巴氯芬下游产品

R-(+)-盐酸巴氯芬文献

Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat.

Eur. J. Pharmacol. 196 , 267, (1991)

In a previous study it was found that i.t. administration of L-baclofen decreased arterial pressure and heart rate while D-baclofen differentially increased arterial pressure. The objective of the pre...

Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations.

J. Neurochem. 47 , 898, (1986)

The affinities of a number of analogues of gamma-aminobutyric acid (GABA) for GABAA and GABAB receptor sites and GABA uptake were studied using rat brain membrane preparations. Studies on the (S)-(+)-...

3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity.

Pol. J. Pharmacol. Pharm. 32 , 187, (1980)

Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enanti...

更多文献