<生产厂家价格>

马来酸氟吡汀

马来酸氟吡汀用途

Flupirtine (D 9998)马来酸盐是神经元钾通道开放剂,同时具有NMDA受体拮抗剂特性。

马来酸氟吡汀名称

[ CAS 号 ]:
75507-68-5

[ 中文名 ]:
马来酸氟吡汀

[ 英文名 ]:
Flupirtine maleate

[中文别名 ]:

木香烃内酯

[英文别名 ]:

Katadolon
Flupirtine maleate
Flupirtine (Maleate)

马来酸氟吡汀生物活性

[ 描述 ]:

Flupirtine (D 9998)马来酸盐是神经元钾通道开放剂,同时具有NMDA受体拮抗剂特性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

信号通路 >> 跨膜转运 >> 钾通道

研究领域 >> 神经疾病

[参考文献]

[1]. Yeung et al (2007) Molecular expression and pharmacological identification of a role for Kv7 channels in murine vascular reactivity. Br.J.Pharmacol. 151 758.

[2]. Gordon R, Sofia RD, Diamantis W.Effect of flupirtine maleate on the nociceptive pathway, EEG, evoked potentials and polysynaptic reflexes in laboratory animals.Postgrad Med J. 1987;63 Suppl 3:49-55.

[3]. Hedges A, Warrington SJ, Turner P, Niebch G.Flupirtine maleate and antipyrine half-life.Eur J Clin Pharmacol. 1987;33(4):437.

[4]. Powell-Jackson P, Williams R.Use of flupirtine maleate as an analgesic in patients with liver disease.Br J Clin Pract. 1985 Feb;39(2):63-6.

[5]. Diamantis W, Gordon R, Sofia RD.Analgesic activity following combined oral administration of flupirtine maleate and peripherally acting analgesics in mice and rats.Postgrad Med J. 1987;63 Suppl 3:29-34.

[相关活性小分子]

马来酸氟吡汀物理化学性质

[ 密度 ]:
1.35 g/cm3

[ 沸点 ]:
434.9ºC at 760 mmHg

[ 熔点 ]:
186-188ºC

[ 分子式 ]:
C₁₉H₂₁FN₄O₆

[ 分子量 ]:
420.392

[ 闪点 ]:
216.8ºC

[ 精确质量 ]:
420.144501

[ PSA ]:
170.59000

[ LogP ]:
2.71190

[ 外观性状 ]:
灰白色结晶粉末

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMSO: soluble >20mg/mL

马来酸氟吡汀MSDS

详细MSDS(安全技术说明书)

马来酸氟吡汀安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
EY8555800

[ 海关编码 ]:
2942000000

马来酸氟吡汀海关

[ 海关编码 ]: 2942000000

马来酸氟吡汀文献

Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.

Am. J. Physiol. Lung Cell. Mol. Physiol. 308(1) , L48-57, (2015)

Hypoxic pulmonary vasoconstriction (HPV) is a beneficial mechanism that diverts blood from hypoxic alveoli to better ventilated areas of the lung, but breathing hypoxic air causes the pulmonary circul...

M channel enhancers and physiological M channel block.

J. Physiol. 590(Pt 4) , 793-807, (2012)

M-type (Kv7, KCNQ) K(+) channels control the resting membrane potential of many neurons, including peripheral nociceptive sensory neurons. Several M channel enhancers were suggested as prospective ana...

M-type potassium channels modulate Schaffer collateral-CA1 glutamatergic synaptic transmission.

J. Physiol. 590(Pt 16) , 3953-64, (2012)

Previous studies have suggested that muscarinic receptor activation modulates glutamatergic transmission. M-type potassium channels mediate the effects of muscarinic activation in the hippocampus, and...

更多文献