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1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮

1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮用途

DNQX是一个AMPA受体的拮抗剂。

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1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮名称

[ CAS 号 ]:
2379-57-9

[ 中文名 ]:
6,7-二硝基奎喔林-2,3(1H,4H)-二酮

[ 英文名 ]:
DNQX

[中文别名 ]:

[英文别名 ]:

6,7-Dinitro-1,4-dihydro-2,3-quinoxalinedione
6,7-dinitroquinoxaline-2,3-diol
2,3-Quinoxalinedione, 1,4-dihydro-6,7-dinitro-
MFCD00069257
6,7-Dinitroquinoxaline-2,3(1H,4H)-dione
6,7-Dinitro-1,4-dihydroquinoxaline-2,3-dione
DNQX

1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮生物活性

[ 描述 ]:

DNQX是一个AMPA受体的拮抗剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 癌症

[参考文献]

[1]. Watkins JC et al. Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. Trends Pharmacol Sci. 1990 Jan;11(1):25-33.

[2]. Honoré T et al. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science. 1988 Aug 5;241(4866):701-3.

[相关活性小分子]

1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
670.7ºC at 760 mmHg

[ 熔点 ]:
>300°C

[ 分子式 ]:
C₈H₄N₄O₆

[ 分子量 ]:
252.141

[ 闪点 ]:
359.4ºC

[ 精确质量 ]:
252.013077

[ PSA ]:
157.36000

[ LogP ]:
1.13

[ 外观性状 ]:
灰白色粉末带有一种黄色色彩

[ 蒸汽压 ]:
1.33E-18mmHg at 25°C

[ 折射率 ]:
1.665

[ 储存条件 ]:
Desiccate at RT

[ 稳定性 ]:
Store in freezer at -20°C

1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮MSDS

1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮合成路线

1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮上下游产品

1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮上游产品

1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮下游产品

1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮文献

Ammonium increases Ca(2+) signalling and upregulates expression of Cav1.2 gene in astrocytes in primary cultures and in the in vivo brain.

Acta Physiol. (Oxf.) 214 , 261-74, (2015)

The primary aim of this study was to identify the effects of hyperammonaemia on functional expression of Cav1.2 L-type Ca(2+) channels in astroglia.Primary cultures of mouse astrocytes were used to st...

Phasic, nonsynaptic GABA-A receptor-mediated inhibition entrains thalamocortical oscillations.

J. Neurosci. 34(21) , 7137-47, (2014)

GABA-A receptors (GABA-ARs) are typically expressed at synaptic or nonsynaptic sites mediating phasic and tonic inhibition, respectively. These two forms of inhibition conjointly control various netwo...

Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.

J. Neurosci. 35(14) , 5664-79, (2015)

The Ca(2+) channelopathies caused by mutations of the CACNA1A gene that encodes the pore-forming subunit of the human Cav2.1 (P/Q-type) voltage-gated Ca(2+) channel include episodic ataxia type 2 (EA2...

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