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(R)-(-)-2-氨基-5-膦酰戊酸

(R)-(-)-2-氨基-5-膦酰戊酸用途

D-AP5 是一个 NMDA 受体拮抗剂。

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(R)-(-)-2-氨基-5-膦酰戊酸名称

[ CAS 号 ]:
79055-68-8

[ 中文名 ]:
(R)-(-)-2-氨基-5-膦酰戊酸

[ 英文名 ]:
D-AP5(mM/ml)

[英文别名 ]:

D(-)-APV
UNII:39PJ29YY8Z
[3H]-D(-)-2-Amino-5-phosphonopentanoic acid
5-Phosphononorvaline
D-2-Amino-5-phosphonovaleric acid
D-2-Amino-5-phosphopentanoic acid
D-Norvaline,5-phosphono
5-Phosphono-D-norvaline
Norvaline, 5-phosphono-
5-PHOSPHONO-DL-NORVALINE

(R)-(-)-2-氨基-5-膦酰戊酸生物活性

[ 描述 ]:

D-AP5 是一个 NMDA 受体拮抗剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

[ 靶点 ]

NMDA[1]

[体内研究]

D-AP5是NMDA受体拮抗剂。慢性脑室内输注D-AP5引起体内空间学习和长期增强(LTP)的平行剂量依赖性损伤。当空间学习被阻止时,脑内D-AP5浓度不能诱导任何可测量的感觉运动干扰[1]。 D-AP5输注与试验中游泳速度的逐渐降低相关。 D-AP5在空间任务中引起感觉运动障碍,但随着动物学习不能逐渐恶化。用D-AP5处理的大鼠在水迷宫的延迟匹配-放置方案中显示出空间记忆的延迟依赖性缺陷[2]。

[动物实验]

在本研究中使用雄性Lister连帽大鼠。它们单独收纳，除手术前12小时外，可随时免费获取食物和水。给动物植入30mM D-AP5（N = 6）并在水迷宫中进行测试[1]。

[参考文献]

[1]. Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34.

[2]. Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17.

[相关活性小分子]

(R)-(-)-2-氨基-5-膦酰戊酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
482.1±55.0 °C at 760 mmHg

[ 分子式 ]:
C₅H₁₂NO₅P

[ 分子量 ]:
197.126

[ 闪点 ]:
245.4±31.5 °C

[ 精确质量 ]:
197.045303

[ PSA ]:
130.66000

[ LogP ]:
-2.32

[ 外观性状 ]:
白色细结晶粉末

[ 蒸汽压 ]:
0.0±2.6 mmHg at 25°C

[ 折射率 ]:
1.536

[ 储存条件 ]:
室温

(R)-(-)-2-氨基-5-膦酰戊酸MSDS

详细MSDS(安全技术说明书)

(R)-(-)-2-氨基-5-膦酰戊酸安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

(R)-(-)-2-氨基-5-膦酰戊酸文献

Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation.

Antioxid. Redox Signal. 22(9) , 772-84, (2015)

Several neurodegenerative disorders show alterations in glutamatergic synapses and increased susceptibility to excitotoxicity. Mounting evidence suggests a central role for the cellular prion protein ...

Properties of a Glutamatergic Synapse Controlling Information Output from Retinal Bipolar Cells.

PLoS ONE 10 , e0129133, (2015)

One general categorization of retinal ganglion cells is to segregate them into tonically or phasically responding neurons, each conveying discrete aspects of the visual scene. Although best identified...

A1 adenosine receptor-mediated GIRK channels contribute to the resting conductance of CA1 neurons in the dorsal hippocampus.

J. Neurophysiol. 113 , 2511-23, (2015)

The dorsal and ventral hippocampi are functionally and anatomically distinct. Recently, we reported that dorsal Cornu Ammonis area 1 (CA1) neurons have a more hyperpolarized resting membrane potential...

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