205304-86-5

205304-86-5结构式

中文名	N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸
英文名	(2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoic acid
中文别名	海洋黏细菌产物 Tubulysin A试剂 (2S,4R)-4-(2-((1R,3R)-1-乙酰氧基-4-甲基-3-((2S,3S)-3-甲基-N-(((3-甲基丁酰基)氧基)甲基)-2-((R)-1-甲基哌啶-2-甲酰胺基)戊酰胺基)戊基)噻唑-4-甲酰胺基)-5-(4-羟苯基)-2-甲基戊酸 N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸/205-5
英文别名	Tubulysins A Benzenentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(3-methyl-1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR) TubA (2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoicaci Tubulysin A,TubA

描述	Tubulysin A(TubA)是黏液性细菌的产物,体外具有抗血管生成、抗有丝分裂、抗增殖的作用。
相关类别	信号通路 >> 抗体- 药物偶联物 >> ADC细胞毒素信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白信号通路 >> 细胞骨架 >> 微管/微管蛋白研究领域 >> 癌症
参考文献	[1]. Kaur G, et al. Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product. Biochem J. 2006 Jun 1;396(2):235-42. [2]. Sasse F, et al. Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 2000 Sep;53(9):879-85. [3]. Khalil MW, et al. Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. Chembiochem. 2006 Apr;7(4):678-83.

符号	GHS06
信号词	Danger
危害声明	H301-H311-H315-H319-H331-H335
警示性声明	P261-P280-P301 + P310-P305 + P351 + P338-P311
个人防护装备	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危害码 (欧洲)	T
风险声明 (欧洲)	23/24/25-36/37/38
安全声明 (欧洲)	36/37-45
危险品运输编码	UN 2811 6.1 / PGIII